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Mouse Monoclonal CD166 antibody [3F8B12] (STJ97907)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
ALCAM antibody, MEMD antibody,|Activated leukocyte cell adhesion molecule antibody|ALCAM antibody|ALCAM protein antibody|CD 166 antibody|CD166 antibody|CD166 antigen antibody|CD166_HUMAN antibody|FLJ3851 antibody|FLJ38514 antibody|MEMD antibody|MGC71733 antibody|Anti-CD166 antibody [EPR2759(2)] (ab109215)
SCBT cat No: sc-74558|sc-25624|sc-74557|sc-8548|
CD166 Monoclonal Antibody
|Catalogue No.|| |
CD166 Monoclonal Antibody detects endogenous levels of CD166 protein.
Purified recombinant fragment of CD166 (aa405-524) expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
CD166 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
CD166 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
CD166 antigen antibody, Activated leukocyte cell adhesion molecule antibody, CD antigen CD166 antibody
|Protein names|| |
CD166 antigen , Activated leukocyte cell adhesion molecule , CD antigen CD166
|Protein function|| |
Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts . Promotes T-cell activation and proliferation via its interactions with CD6 . Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 . Mediates homotypic interactions with cells that express ALCAM . Required for normal hematopoietic stem cell engraftment in the bone marrow . Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction . Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions . Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity). / Isoform 3: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation.
|Protein tissue specificity|| |
Detected on hematopoietic stem cells derived from umbilical cord blood (PubMed:24740813). Detected on lymph vessel endothelial cells, skin and tonsil (PubMed:23169771). Detected on peripheral blood monocytes (PubMed:15048703). Detected on monocyte-derived dendritic cells (at protein level) (PubMed:16352806). Detected at low levels in spleen, placenta, liver (PubMed:9502422). Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells (PubMed:7760007). Isoform 1 and isoform 3 are detected in vein and artery endothelial cells, astrocytes, keratinocytes and artery smooth muscle cells (PubMed:15496415). Expressed by neurons in the brain. Restricted expression in tumor cell lines. Detected in highly metastasizing melanoma cell lines (PubMed:9502422).
|Protein sequence and domain|| |
The CD6 binding site is located in the N-terminal Ig-like domain. / Contains 3 Ig-like C2-type (immunoglobulin-like) domains. / Contains 2 Ig-like V-type (immunoglobulin-like) domains.
|Protein post-translational modifications|| |
|Protein cellular localization|| |
Cell membrane / Single-pass type I membrane protein / Cell projection > axon / Cell projection > dendrite / Secreted
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St John’s Laboratory Ltd.
|Product type|| |
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