Mouse Monoclonal CD166 antibody [3F8B12] (STJ97907)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal CD166 antibody [3F8B12] (STJ97907)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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ALCAM antibody, MEMD antibody,|Activated leukocyte cell adhesion molecule antibody|ALCAM antibody|ALCAM protein antibody|CD 166 antibody|CD166 antibody|CD166 antigen antibody|CD166_HUMAN antibody|FLJ3851 antibody|FLJ38514 antibody|MEMD antibody|MGC71733 antibody|Anti-CD166 antibody [EPR2759(2)] (ab109215)
SCBT cat No: sc-74558|sc-25624|sc-74557|sc-8548|

 

Name

CD166 Monoclonal Antibody

Catalogue No.

STJ97907

Reactivity

Human

Specificity

CD166 Monoclonal Antibody detects endogenous levels of CD166 protein.

Immunogen

Purified recombinant fragment of CD166 (aa405-524) expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG2a

Formulation

CD166 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

CD166 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

CD166 antigen antibody, Activated leukocyte cell adhesion molecule antibody, CD antigen CD166 antibody

Database links

Human UniProt/Swiss-Prot:Q13740;Mouse UniPort/Swiss-Prot: Q61490;Rat UniProt/Swiss-Port: O35112;Human Entrez Gene: 214;Mouse Entrez Gene: 11658;Rat Entrez Gene: Rn.5789

Protein names

CD166 antigen , Activated leukocyte cell adhesion molecule , CD antigen CD166

Protein function

Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts . Promotes T-cell activation and proliferation via its interactions with CD6 . Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 . Mediates homotypic interactions with cells that express ALCAM . Required for normal hematopoietic stem cell engraftment in the bone marrow . Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction . Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions . Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity). / Isoform 3: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation.

Protein tissue specificity

Detected on hematopoietic stem cells derived from umbilical cord blood (PubMed:24740813). Detected on lymph vessel endothelial cells, skin and tonsil (PubMed:23169771). Detected on peripheral blood monocytes (PubMed:15048703). Detected on monocyte-derived dendritic cells (at protein level) (PubMed:16352806). Detected at low levels in spleen, placenta, liver (PubMed:9502422). Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells (PubMed:7760007). Isoform 1 and isoform 3 are detected in vein and artery endothelial cells, astrocytes, keratinocytes and artery smooth muscle cells (PubMed:15496415). Expressed by neurons in the brain. Restricted expression in tumor cell lines. Detected in highly metastasizing melanoma cell lines (PubMed:9502422).

Protein sequence and domain

The CD6 binding site is located in the N-terminal Ig-like domain. / Contains 3 Ig-like C2-type (immunoglobulin-like) domains. / Contains 2 Ig-like V-type (immunoglobulin-like) domains.

Protein post-translational modifications

Glycosylated.

Protein cellular localization

Cell membrane / Single-pass type I membrane protein / Cell projection > axon / Cell projection > dendrite / Secreted

Research area

All research areas>Cell Adhesion Proteins>ALCAM
(View all antibody categories related to Cell Adhesion Proteins)

Note

AntibodyPlus can customize CD166 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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