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Mouse Monoclonal CD33 antibody [2B7C12] (STJ97921)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
CD33 antibody, SIGLEC3 antibody,|CD 33 antibody|CD33 antibody|CD33 antigen (gp67) antibody|CD33 antigen antibody|CD33 molecule antibody|CD33_HUMAN antibody|FLJ00391 antibody|gp67 antibody|My9 antibody|Myeloid cell surface antigen CD33 antibody|Myeloid cell surface antigen CD33 precursor antibody|Myeloid differentiation antigen CD33 antibody|p67 antibody|Sialic acid binding Ig like lectin 3 antibody|Sialic acid binding immunoglobulin like lectin 3 antibody|Sialic acid-binding Ig-like lectin 3 antibody|SIGLEC 3 antibody|Siglec-3 antibody|SIGLEC3 antibody|Anti-CD33 antibody [SP266] (ab199432)
SCBT cat No: sc-53199|sc-514119|sc-374450|sc-7038|sc-59020|sc-7041|sc-376184|sc-28811|sc-7040|
CD33 Monoclonal Antibody
|Catalogue No.|| |
CD33 Monoclonal Antibody detects endogenous levels of CD33 protein.
Purified recombinant fragment of CD33 (48-258) expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
CD33 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
CD33 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Myeloid cell surface antigen CD33 antibody, Sialic acid-binding Ig-like lectin 3 antibody, Siglec-3 antibody, gp67 antibody, CD antigen CD33 antibody
|Protein names|| |
Myeloid cell surface antigen CD33 , Sialic acid-binding Ig-like lectin 3 , Siglec-3 , gp67 , CD antigen CD33
|Protein function|| |
Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
|Protein tissue specificity|| |
Monocytic/myeloid lineage cells.
|Protein sequence and domain|| |
Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. / Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. / Contains 1 Ig-like C2-type (immunoglobulin-like) domain. / Contains 1 Ig-like V-type (immunoglobulin-like) domain.
|Protein post-translational modifications|| |
Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6.
|Protein cellular localization|| |
Cell membrane; Single-pass type I membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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