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Mouse Monoclonal CD45 antibody [4A8A4C7A2] (STJ97930)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for CD45 Monoclonal Antibody.
Check alternative names for the antibodyExpand
PTPRC antibody, CD45 antibody,|B220 antibody|CD45 antibody|cd45 antigen antibody|CD45R antibody|GP180 antibody|L-CA antibody|lca antibody|Leukocyte common antigen antibody|LY 5 antibody|LY5 antibody|Protein tyrosine phosphatase, receptor type, C antibody|Protein tyrosine phosphatase, receptor type, c polypeptide antibody|Ptprc antibody|PTPRC_HUMAN antibody|Receptor-type tyrosine-protein phosphatase C antibody|T200 antibody|T200 glycoprotein antibody|T200 leukocyte common antigen antibody|Anti-CD45 antibody (ab10558)
SCBT cat No: sc-53665|sc-53201|sc-1178|sc-70699|sc-70700|sc-28369|sc-52490|sc-25590|sc-52491|
CD45 Monoclonal Antibody
|Catalogue No.|| |
CD45 Monoclonal Antibody detects endogenous levels of CD45 protein.
Purified recombinant fragment of CD45 expressed in E Coli
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
CD45 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
CD45 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Receptor-type tyrosine-protein phosphatase C antibody, Leukocyte common antigen antibody, L-CA antibody, T200 antibody, CD antigen CD45 antibody
|Protein names|| |
Receptor-type tyrosine-protein phosphatase C , Leukocyte common antigen , L-CA , T200 , CD antigen CD45
|Protein function|| |
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). / Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
|Involvement in disease|| |
Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Multiple sclerosis (MS) [MIM:126200]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. . Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The first PTPase domain interacts with SKAP1. / Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily. / Contains 2 fibronectin type-III domains. / Contains 2 tyrosine-protein phosphatase domains.
|Protein post-translational modifications|| |
Heavily N- and O-glycosylated.
|Protein cellular localization|| |
Membrane / Single-pass type I membrane protein / Membrane raft
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St John’s Laboratory Ltd.
|Product type|| |
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