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Mouse Monoclonal CD71 antibody [2H9] (STJ97934)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, FC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
TFRC antibody,|CD 71 antibody|CD71 antibody|CD71 antigen antibody|OTTHUMP00000208523 antibody|OTTHUMP00000208524 antibody|OTTHUMP00000208525 antibody|p90 antibody|sTfR antibody|T9 antibody|TFR 1 antibody|TfR antibody|TfR1 antibody|TFR1_HUMAN antibody|TFRC antibody|TR antibody|Transferrin receptor (p90 CD71) antibody|Transferrin receptor protein 1, serum form antibody|Trfr antibody|Anti-Transferrin Receptor antibody (ab84036)
SCBT cat No: sc-70778|sc-65877|sc-19675|
CD71 Monoclonal Antibody
|Catalogue No.|| |
CD71 Monoclonal Antibody detects endogenous levels of CD71 protein.
Purified recombinant fragment of human CD71 expressed in E Coli
WB, IHC, IF, FC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
CD71 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
CD71 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Transferrin receptor protein 1 antibody, TR antibody, TfR antibody, TfR1 antibody, Trfr antibody, T9 antibody, p90 antibody, CD antigen CD71 antibody
|Protein names|| |
Transferrin receptor protein 1 , TR , TfR , TfR1 , Trfr , T9 , p90 , CD antigen CD71
|Protein function|| |
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. / (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.
|Protein tissue specificity|| |
Regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3′-UTR. Up-regulated upon mitogenic stimulation.
|Involvement in disease|| |
Immunodeficiency 46 (IMD46) [MIM:616740]: An autosomal recessive primary immunodeficiency disorder characterized by early-onset chronic diarrhea, recurrent infections, hypo- or agammaglobulinemia, normal lymphocyte counts, intermittent neutropenia, and intermittent thrombocytopenia. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the peptidase M28 family. M28B subfamily. / Contains 1 PA (protease associated) domain.
|Protein post-translational modifications|| |
N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated. / Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR). / Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.
|Protein cellular localization|| |
Cell membrane / Single-pass type II membrane protein / Melanosome / Secreted
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St John’s Laboratory Ltd.
|Product type|| |
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