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Mouse Monoclonal CDC25C antibody [1F12] (STJ97944)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for CDC25C Monoclonal Antibody.
Check alternative names for the antibodyExpand
CDC25C antibody,|CDC 25 antibody|Cdc 25C antibody|CDC25 antibody|CDC25C antibody|Cell division cycle 25 homolog C antibody|Cell division cycle 25C antibody|Cell division cycle 25C protein antibody|Dual specificity phosphatase Cdc25C antibody|M phase inducer phosphatase 3 antibody|M-phase inducer phosphatase 3 antibody|Mitosis inducer CDC25 antibody|MPIP3 antibody|MPIP3_HUMAN antibody|Phosphotyrosine phosphatase antibody|PPP1R60 antibody|protein phosphatase 1, regulatory subunit 60 antibody|Anti-Cdc25C antibody [E302] (ab32444)
SCBT cat No: sc-327|sc-55513|sc-5620|sc-13138|sc-56269|sc-377338|
CDC25C Monoclonal Antibody
|Catalogue No.|| |
CDC25C Monoclonal Antibody detects endogenous levels of CDC25C protein.
Purified recombinant fragment of human CDC25C expressed in E Coli
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
CDC25C Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
CDC25C Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
M-phase inducer phosphatase 3 antibody, Dual specificity phosphatase Cdc25C antibody
|Protein names|| |
M-phase inducer phosphatase 3 , Dual specificity phosphatase Cdc25C
|Protein function|| |
Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity. / Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
|Protein tissue specificity|| |
Expressed predominantly in G2 phase.
|Protein sequence and domain|| |
Belongs to the MPI phosphatase family. / Contains 1 rhodanese domain.
|Protein post-translational modifications|| |
Phosphorylated by CHEK1 and MAPK14 at Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4. Phosphorylated by PLK1, leading to activate the phosphatase activity. Phosphorylation by PLK3 at Ser-191 promotes nuclear translocation. Ser-198 is a minor phosphorylation site. Was initially reported to be phosphorylated by PLK3 at Ser-216 . However, such phosphorylation by PLK3 was not confirmed by other groups. Phosphorylation at Thr-48, Thr-67, Ser-122, Thr-130, Ser-168 and Ser-214 occurs at G2 and G2-M transition and is probably catalyzed by CDK1. Ser-168 phosphorylation levels are lower than those at the other 5 CDK1 sites. Phosphorylation by CDK1 leads to increased activity.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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