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Mouse Monoclonal CHRDL1 antibody (STJ98478)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB
Recommended dilution: WB 1:1000-1:2000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
CHRDL1 antibody, NRLN1 antibody,|CHL antibody|chordin like 1 antibody|Chordin-like protein 1 antibody|CHRDL1 antibody|CRDL1_HUMAN antibody|dA141H5.1 antibody|neuralin 1 antibody|Neuralin-1 antibody|Neurogenesin-1 antibody|NRLN1 antibody|Ventroptin antibody|VOPT antibody|Anti-CHRDL1 antibody (ab103369)
SCBT cat No: sc-100333|
CHRDL1 Monoclonal Antibody
|Catalogue No.|| |
CHRDL1 Monoclonal Antibody detects endogenous levels of CHRDL1 protein.
Purified recombinant human CHRDL1 protein fragments expressed in Ecoli
|Recommended dilution|| |
CHRDL1 Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
CHRDL1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Chordin-like protein 1 antibody, Neuralin-1 antibody, Neurogenesin-1 antibody, Ventroptin antibody
|Protein names|| |
Chordin-like protein 1 , Neuralin-1 , Neurogenesin-1 , Ventroptin
|Protein function|| |
Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development.
|Protein tissue specificity|| |
Expressed in the developing cornea and in the eye anterior segment in addition to the retina. Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in retinal pericytes.
|Involvement in disease|| |
Megalocornea 1, X-linked (MGC1) [MIM:309300]: An eye disorder in which the corneal diameter is bilaterally enlarged (greater than 13 mm) without an increase in intraocular pressure. It may also be referred to as anterior megalophthalmos, since the entire anterior segment is larger than normal. Features of megalocornea in addition to a deep anterior chamber include astigmatic refractive errors, atrophy of the iris stroma, miosis secondary to decreased function of the dilator muscle, iridodonesis, and tremulousness, subluxation, or dislocation of the lens. Whereas most affected individuals exhibit normal ocular function, complications include cataract development and glaucoma following lenticular dislocation or subluxation. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Contains 3 VWFC domains.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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