Mouse Monoclonal CHRDL1 antibody (STJ98478)

$379.00

Reactivity: Human, Rat
Applications: WB
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal CHRDL1 antibody (STJ98478)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB

Recommended dilution: WB 1:1000-1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CHRDL1 antibody, NRLN1 antibody,|CHL antibody|chordin like 1 antibody|Chordin-like protein 1 antibody|CHRDL1 antibody|CRDL1_HUMAN antibody|dA141H5.1 antibody|neuralin 1 antibody|Neuralin-1 antibody|Neurogenesin-1 antibody|NRLN1 antibody|Ventroptin antibody|VOPT antibody|Anti-CHRDL1 antibody (ab103369)
SCBT cat No: sc-100333|

 

Name

CHRDL1 Monoclonal Antibody

Catalogue No.

STJ98478

Reactivity

Human, Rat

Specificity

CHRDL1 Monoclonal Antibody detects endogenous levels of CHRDL1 protein.

Immunogen

Purified recombinant human CHRDL1 protein fragments expressed in Ecoli

Host

Mouse

Applications

WB

Recommended dilution

WB 1:1000-1:2000

Clonality

Monoclonal

Conjugation

Unconjugated

Formulation

CHRDL1 Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Concentration

1 mg/ml

Purification

CHRDL1 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Chordin-like protein 1 antibody, Neuralin-1 antibody, Neurogenesin-1 antibody, Ventroptin antibody

Database links

Human UniProt/Swiss-Prot:Q9BU40;Mouse UniPort/Swiss-Prot: Q920C1;Rat UniProt/Swiss-Port: Q76LD0;Human Entrez Gene: 91851;Mouse Entrez Gene: 83453;Rat Entrez Gene: Rn.211154

Protein names

Chordin-like protein 1 , Neuralin-1 , Neurogenesin-1 , Ventroptin

Protein function

Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development.

Protein tissue specificity

Expressed in the developing cornea and in the eye anterior segment in addition to the retina. Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in retinal pericytes.

Involvement in disease

Megalocornea 1, X-linked (MGC1) [MIM:309300]: An eye disorder in which the corneal diameter is bilaterally enlarged (greater than 13 mm) without an increase in intraocular pressure. It may also be referred to as anterior megalophthalmos, since the entire anterior segment is larger than normal. Features of megalocornea in addition to a deep anterior chamber include astigmatic refractive errors, atrophy of the iris stroma, miosis secondary to decreased function of the dilator muscle, iridodonesis, and tremulousness, subluxation, or dislocation of the lens. Whereas most affected individuals exhibit normal ocular function, complications include cataract development and glaucoma following lenticular dislocation or subluxation. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Contains 3 VWFC domains.

Protein cellular localization

Secreted

Research area

All research areas>Neurobiology>CHRDL
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize CHRDL1 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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