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Mouse Monoclonal CIB1 antibody [5A1F5E12; 5A1H7E12] (STJ97957)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
CIB1 antibody, CIB antibody, KIP antibody, PRKDCIP antibody,|Calcium and integrin binding 1 (calmyrin) antibody|Calcium and integrin binding protein 1 antibody|Calcium and integrin-binding protein 1 antibody|Calcium- and integrin-binding protein antibody|Calmyrin antibody|CIB antibody|CIB1 antibody|CIB1_HUMAN antibody|CIBP antibody|DNA PKcs interacting protein antibody|DNA-dependent protein kinase interacting protein antibody|DNA-PK interaction protein antibody|DNA-PKcs-interacting protein antibody|Human Snk interacting protein 2 to 28 mRNA complete cds antibody|Kinase interacting protein antibody|Kinase-interacting protein 1 antibody|Kinase-interacting protein antibody|KIP antibody|KIP1 antibody|PRKDCIP antibody|SIP2 28 antibody|SIP2-28 antibody|SNK interacting protein 2 to 28 antibody|SNK-interacting protein 2-28 antibody|Anti-CIB1 antibody (ab56664)
SCBT cat No: sc-65998|sc-271041|sc-271490|sc-33551|
CIB1 Monoclonal Antibody
|Catalogue No.|| |
CIB1 Monoclonal Antibody detects endogenous levels of CIB1 protein.
Purified recombinant fragment of CIB1 expressed in E Coli
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
CIB1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
CIB1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Calcium and integrin-binding protein 1 antibody, CIB antibody, Calcium- and integrin-binding protein antibody, CIBP antibody, Calmyrin antibody, DNA-PKcs-interacting protein antibody, Kinase-interacting protein antibody, KIP antibody, SNK-interacting protein 2-28 antibody, SIP2-28 antibody
|Protein names|| |
Calcium and integrin-binding protein 1 , CIB , Calcium- and integrin-binding protein , CIBP , Calmyrin , DNA-PKcs-interacting protein , Kinase-interacting protein , KIP , SNK-interacting protein 2-28 , SIP2-28
|Protein function|| |
Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells. / Isoform 2: Plays a regulatory role in angiogenesis and tumor growth by mediating PKD/PRKD2-induced vascular endothelial growth factor A (VEGFA) secretion.
|Protein tissue specificity|| |
Detected in platelets and in cell lines of megakaryocytic and erythrocytic lineages. Both isoform 1 and isoform 2 are detected in various cancer cell lines, with isoform 2 being the predominant form (at protein level). Ubiquitously expressed.
|Protein sequence and domain|| |
The EF-hands may also bind magnesium ions in the presence of high Mg2+ levels and low Ca2+ levels. / Contains 2 EF-hand domains.
|Protein post-translational modifications|| |
Phosphorylation of isoform 2 at Ser-78 by PRKD2 increases its ability to stimulate tumor angiogenesis.
|Protein cellular localization|| |
Membrane; Lipid-anchor / Cell membrane > sarcolemma / Cell membrane / Apical cell membrane / Cell projection > ruffle membrane / Cell projection > filopodium tip / Cell projection > growth cone / Cell projection > lamellipodium / Cytoplasm / Cytoplasm > cytoskeleton / Cytoplasm > cytoskeleton > microtubule organizing center > centrosome / Cytoplasm > perinuclear region / Nucleus / Cytoplasm > perinuclear region / Golgi apparatus > trans-Golgi network
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St John’s Laboratory Ltd.
|Product type|| |
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