Mouse Monoclonal CK17 antibody [10A1] (STJ96983)

$99.00$319.00

Reactivity: Human
Applications: WB, IHC, IF
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal CK17 antibody [10A1] (STJ96983)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IP

Recommended dilution: WB 1:1000; IP 1:200

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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KRT17 antibody,|39.1 antibody|CK 17 antibody|CK-17 antibody|Cytokeratin-17 antibody|K17 antibody|K1C17_HUMAN antibody|Keratin 17 antibody|keratin 17 epitope S1 antibody|keratin 17 epitope S2 antibody|keratin 17 epitope S4 antibody|Keratin 17, type I antibody|Keratin antibody|Keratin type I cytoskeletal 17 antibody|keratin, type i cytoskeletal 17 [version 1] antibody|Keratin-17 antibody|KRT17 antibody|PC antibody|PC2 antibody|PCHC1 antibody|type I cytoskeletal 17 antibody|Anti-Cytokeratin 17 antibody [EP1623] – Cytoskeleton Marker (ab109725)
SCBT cat No: sc-393091|sc-58726|sc-393002|sc-366511|sc-101461|

Name

CK17 Monoclonal Antibody

Catalogue No.

STJ96983

Reactivity

Human

Specificity

The antibody detects CK17 endogenous proteins.

Immunogen

Synthetic Peptide

Host

Mouse

Applications

WB, IP

Recommended dilution

WB 1:1000; IP 1:200

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

CK17 Antibody was tube-contained. PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Purification

CK17 Antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Keratin, type I cytoskeletal 17 antibody, 39.1 antibody, Cytokeratin-17 antibody, CK-17 antibody, Keratin-17 antibody, K17 antibody

Database links

Human UniProt/Swiss-Prot:Q04695;Mouse UniPort/Swiss-Prot: Q9QWL7;Rat UniProt/Swiss-Port: Q6IFU8;Human Entrez Gene: 3872;Mouse Entrez Gene: 16667;Rat Entrez Gene: Rn.106755

Protein names

Keratin, type I cytoskeletal 17 , 39.1 , Cytokeratin-17 , CK-17 , Keratin-17 , K17

Protein function

Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial “stem cells”. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.

Protein tissue specificity

Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).

Involvement in disease

Pachyonychia congenita 2 (PC2) [MIM:167210]: An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma and hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse eyebrow and body hair, and by the presence of natal teeth. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Steatocystoma multiplex (SM) [MIM:184500]: Disease characterized by round or oval cystic tumors widely distributed on the back, anterior trunk, arms, scrotum, and thighs. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Note: KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.

Protein sequence and domain

Belongs to the intermediate filament family.

Protein post-translational modifications

Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.

Protein cellular localization

Cytoplasm

Research area

All research areas>Lymphocyte Signaling>EAT
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize CK17 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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Immunofluorescence analysis of Human breast tissue

1: CK17 Monoclonal Antibody(10A1)(red) was diluted at 1:200 (4 degree Celsius,overnight).
2: Cy3 labled Secondary antibody was diluted at 1:300 (room temperature, 50min).
3: Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B.
 

Immunofluorescence analysis of Human breast tissue

1: CK17 Monoclonal Antibody(10A1)(red) was diluted at 1:200 (4 degree Celsius,overnight).
2: Cy3 labled Secondary antibody was diluted at 1:300 (room temperature, 50min).
3: Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B.
 

Immunofluorescence analysis of Human breast tissue

1: CK17 Monoclonal Antibody(10A1)(red) was diluted at 1:200 (4 degree Celsius,overnight).
2: Cy3 labled Secondary antibody was diluted at 1:300 (room temperature, 50min).
3: Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B.
 

Immunofluorescence analysis of Human lung cancer tissue

1: CK17 Monoclonal Antibody(10A1)(red) was diluted at 1:200 (4 degree Celsius,overnight).
2: Cy3 labled Secondary antibody was diluted at 1:300 (room temperature, 50min).
3: Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B.
 

Immunofluorescence analysis of Human lung cancer tissue

1: CK17 Monoclonal Antibody(10A1)(red) was diluted at 1:200 (4 degree Celsius,overnight).
2: Cy3 labled Secondary antibody was diluted at 1:300 (room temperature, 50min).
3: Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B.
 

Immunofluorescence analysis of Human lung cancer tissue

1: CK17 Monoclonal Antibody(10A1)(red) was diluted at 1:200 (4 degree Celsius,overnight).
2: Cy3 labled Secondary antibody was diluted at 1:300 (room temperature, 50min).
3: Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B.
 

Immunohistochemical analysis of paraffin embedded Human liver tissue

1: CK17 Monoclonal Antibody(10A1) was diluted at 1:200 (4 degree Celsius,overnight).
2: Sodium citrate pH 6.0 was used for antibody retrieval (>98 degree Celsius,20min).
3: Secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.
 

Immunohistochemical analysis of paraffin embedded Human liver cancer tissue

1: CK17 Monoclonal Antibody(10A1) was diluted at 1:200 (4 degree Celsius,overnight).
2: Sodium citrate pH 6.0 was used for antibody retrieval (>98 degree Celsius,20min).
3: Secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.
 

Immunohistochemical analysis of paraffin embedded Human lung cancer tissue

1: CK17 Monoclonal Antibody(10A1) was diluted at 1:200 (4 degree Celsius,overnight).
2: Sodium citrate pH 6.0 was used for antibody retrieval (>98 degree Celsius,20min).
3: Secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.
 

Immunohistochemical analysis of paraffin embedded Human kidney tissue

1: CK17 Monoclonal Antibody(10A1) was diluted at 1:200 (4 degree Celsius,overnight).
2: Sodium citrate pH 6.0 was used for antibody retrieval (>98 degree Celsius,20min).
3: Secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.


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