Mouse Monoclonal Csk antibody [5F3] (STJ97972)

$379.00

Reactivity: Human, Mouse, Rat, Monkey
Applications: WB, IF, FC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Csk antibody [5F3] (STJ97972)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IF, FC, ELISA

Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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CSK antibody,|C SRC antibody|C SRC kinase antibody|C src Tyrosine Kinase antibody|C-SRC kinase antibody|c-src tyrosine kinase antibody|Csk A antibody|CSK antibody|CSK_HUMAN antibody|CYTOPLASMIC TYROSINE KINASE antibody|EC 2.7.10.2 antibody|MGC112926 antibody|MGC117393 antibody|MGC154049 antibody|P60 Src antibody|Protein tyrosine kinase CYL antibody|Protein-tyrosine kinase CYL antibody|Proto oncogene tyrosine protein kinase antibody|Tyrosine protein kinase CSK antibody|Tyrosine-protein kinase CSK antibody|zgc:154049 antibody|Anti-CSK antibody (ab744)
SCBT cat No: sc-166513|sc-286|sc-51580|sc-166560|sc-13074|sc-9897|

 

Name

Csk Monoclonal Antibody

Catalogue No.

STJ97972

Reactivity

Human, Mouse, Rat, Monkey

Specificity

Csk Monoclonal Antibody detects endogenous levels of Csk protein.

Immunogen

Purified recombinant fragment of human Csk expressed in E Coli

Host

Mouse

Applications

WB, IF, FC, ELISA

Recommended dilution

WB 1:500-1:2000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

Csk Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

Csk Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Tyrosine-protein kinase CSK antibody, C-Src kinase antibody, Protein-tyrosine kinase CYL antibody

Database links

Human UniProt/Swiss-Prot:P41240;Mouse UniPort/Swiss-Prot: P41241;Rat UniProt/Swiss-Port: P32577;Human Entrez Gene: 1445;Mouse Entrez Gene: 12988;Rat Entrez Gene: Rn.2759

Protein names

Tyrosine-protein kinase CSK , C-Src kinase , Protein-tyrosine kinase CYL

Protein function

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. / Mg2+

Protein tissue specificity

Expressed in lung and macrophages.

Protein sequence and domain

The architecture of this protein is similar to that of Src-family kinases (SFKs) with one N-terminal SH3 domain, one SH2 domain, and a C-terminal kinase domain. / Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily. / Contains 1 protein kinase domain. / Contains 1 SH2 domain. / Contains 1 SH3 domain.

Protein post-translational modifications

Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated.

Protein cellular localization

Cytoplasm / Cell membrane

Research area

All research areas>Kinases and Phosphatases>Csk
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize Csk Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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