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Mouse Monoclonal Cyclin D3 antibody [6H4] (STJ97979)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for Cyclin D3 Monoclonal Antibody.
Check alternative names for the antibodyExpand
CCND3 antibody,|CCND 3 antibody|Ccnd3 antibody|CCND3_HUMAN antibody|CyclinD3 antibody|D3 type cyclin antibody|G1 S specific cyclin D3 antibody|G1/S specific cyclin D3 antibody|G1/S-specific cyclin-D3 antibody|Anti-Cyclin D3 antibody [DCS2.2] (ab28283)
SCBT cat No: sc-135875|sc-453|sc-182|sc-6283|sc-56307|sc-56308|sc-755|
Cyclin D3 Monoclonal Antibody
|Catalogue No.|| |
Cyclin D3 Monoclonal Antibody detects endogenous levels of Cyclin D3 protein.
Purified recombinant fragment of human Cyclin D3 expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
Cyclin D3 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Cyclin D3 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
G1/S-specific cyclin-D3 antibody
|Protein names|| |
|Protein function|| |
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
|Protein sequence and domain|| |
Belongs to the cyclin family. Cyclin D subfamily. / Contains 1 cyclin N-terminal domain.
|Protein post-translational modifications|| |
Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.
|Protein cellular localization|| |
Nucleus / Cytoplasm / Membrane
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St John’s Laboratory Ltd.
|Product type|| |
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