Mouse Monoclonal Cyclin D3 antibody [6H4] (STJ97979)

$379.00

Reactivity: Human, Mouse
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Cyclin D3 antibody [6H4] (STJ97979)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Cyclin D3 Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody

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CCND3 antibody,|CCND 3 antibody|Ccnd3 antibody|CCND3_HUMAN antibody|CyclinD3 antibody|D3 type cyclin antibody|G1 S specific cyclin D3 antibody|G1/S specific cyclin D3 antibody|G1/S-specific cyclin-D3 antibody|Anti-Cyclin D3 antibody [DCS2.2] (ab28283)
SCBT cat No: sc-135875|sc-453|sc-182|sc-6283|sc-56307|sc-56308|sc-755|

 

Name

Cyclin D3 Monoclonal Antibody

Catalogue No.

STJ97979

Reactivity

Human, Mouse

Specificity

Cyclin D3 Monoclonal Antibody detects endogenous levels of Cyclin D3 protein.

Immunogen

Purified recombinant fragment of human Cyclin D3 expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

Cyclin D3 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

Cyclin D3 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

G1/S-specific cyclin-D3 antibody

Database links

Human UniProt/Swiss-Prot:P30281;Mouse UniPort/Swiss-Prot: P30282;Rat UniProt/Swiss-Port: P48961;Human Entrez Gene: 896;Mouse Entrez Gene: 12445;Rat Entrez Gene: Rn.3483

Protein names

G1/S-specific cyclin-D3

Protein function

Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Protein sequence and domain

Belongs to the cyclin family. Cyclin D subfamily. / Contains 1 cyclin N-terminal domain.

Protein post-translational modifications

Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.

Protein cellular localization

Nucleus / Cytoplasm / Membrane

Research area

All research areas>Cell Cycle Proteins>Cyclin
(View all antibody categories related to Cell Cycle Proteins)

Note

AntibodyPlus can customize Cyclin D3 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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