Mouse Monoclonal Cytokeratin 17 antibody [3B12] (STJ97983)

$379.00

Reactivity: Human
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Cytokeratin 17 antibody [3B12] (STJ97983)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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KRT17 antibody,|39.1 antibody|CK 17 antibody|CK-17 antibody|Cytokeratin-17 antibody|K17 antibody|K1C17_HUMAN antibody|Keratin 17 antibody|keratin 17 epitope S1 antibody|keratin 17 epitope S2 antibody|keratin 17 epitope S4 antibody|Keratin 17, type I antibody|Keratin antibody|Keratin type I cytoskeletal 17 antibody|keratin, type i cytoskeletal 17 [version 1] antibody|Keratin-17 antibody|KRT17 antibody|PC antibody|PC2 antibody|PCHC1 antibody|type I cytoskeletal 17 antibody|Anti-Cytokeratin 17 antibody [EP1623] – Cytoskeleton Marker (ab109725)
SCBT cat No: sc-393091|sc-58726|sc-393002|sc-366511|sc-101461|

 

Name

Cytokeratin 17 Monoclonal Antibody

Catalogue No.

STJ97983

Reactivity

Human

Specificity

Cytokeratin 17 Monoclonal Antibody detects endogenous levels of Cytokeratin 17 protein.

Immunogen

Purified recombinant fragment of Cytokeratin 17 expressed in E Coli

Host

Mouse

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG2b

Formulation

Cytokeratin 17 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

Cytokeratin 17 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Keratin, type I cytoskeletal 17 antibody, 39.1 antibody, Cytokeratin-17 antibody, CK-17 antibody, Keratin-17 antibody, K17 antibody

Database links

Human UniProt/Swiss-Prot:Q04695;Mouse UniPort/Swiss-Prot: Q9QWL7;Rat UniProt/Swiss-Port: Q6IFU8;Human Entrez Gene: 3872;Mouse Entrez Gene: 16667;Rat Entrez Gene: Rn.106755

Protein names

Keratin, type I cytoskeletal 17 , 39.1 , Cytokeratin-17 , CK-17 , Keratin-17 , K17

Protein function

Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial “stem cells”. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.

Protein tissue specificity

Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).

Involvement in disease

Pachyonychia congenita 2 (PC2) [MIM:167210]: An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma and hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse eyebrow and body hair, and by the presence of natal teeth. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Steatocystoma multiplex (SM) [MIM:184500]: Disease characterized by round or oval cystic tumors widely distributed on the back, anterior trunk, arms, scrotum, and thighs. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Note: KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.

Protein sequence and domain

Belongs to the intermediate filament family.

Protein post-translational modifications

Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.

Protein cellular localization

Cytoplasm

Research area

All research areas>Structural Proteins>Cytokeratin
(View all antibody categories related to Structural Proteins)

Note

AntibodyPlus can customize Cytokeratin 17 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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