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Mouse Monoclonal DBC-1 antibody (STJ98485)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB
Recommended dilution: WB 1:1000-1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for DBC-1 Monoclonal Antibody.
Check alternative names for the antibodyExpand
CCAR2 antibody, DBC1 antibody, KIAA1967 antibody,|CCAR2 antibody|Cell cycle and apoptosis regulator 2 antibody|Cell division cycle and apoptosis regulator protein 2 antibody|DBC-1 antibody|DBC.1 antibody|DBC1 antibody|DBIRD complex subunit KIAA1967 antibody|Deleted in breast cancer 1 antibody|Deleted in breast cancer gene 1 protein antibody|K1967_HUMAN antibody|KIAA1967 antibody|NET35 antibody|p30 DBC antibody|p30 DBC protein antibody|p30DBC antibody|Anti-KIAA1967 antibody [EPR19747] (ab215852)
SCBT cat No: sc-67373|sc-166733|sc-54067|
DBC-1 Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat, Cow, Dog, Pig
DBC-1 Monoclonal Antibody detects endogenous levels of DBC-1 protein.
Purified recombinant human DBC-1 (N-terminus) protein fragments expressed in Ecoli
|Recommended dilution|| |
DBC-1 Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
DBC-1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Cell cycle and apoptosis regulator protein 2 antibody, Cell division cycle and apoptosis regulator protein 2 antibody, DBIRD complex subunit KIAA1967 antibody, Deleted in breast cancer gene 1 protein antibody, DBC-1 antibody, DBC.1 antibody, NET35 antibody, p30 DBC antibody
|Protein names|| |
Cell cycle and apoptosis regulator protein 2 , Cell division cycle and apoptosis regulator protein 2 , DBIRD complex subunit KIAA1967 , Deleted in breast cancer gene 1 protein , DBC-1 , DBC.1 , NET35 , p30 DBC
|Protein function|| |
Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation . Represses the ligand-dependent transcriptional activation function of ESR2 . Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 . Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization . Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway . Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 . Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 . Represses the transcriptional activator activity of BRCA1 . Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro .
|Protein tissue specificity|| |
Expressed in gastric carcinoma tissue and the expression gradually increases with the progression of the carcinoma (at protein level). Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues.
|Protein post-translational modifications|| |
ATM/ATR-mediated phosphorylation at Thr-454 upon DNA damage promotes binding to SIRT1. Phosphorylation at Thr-454 promotes its sumoylation by switching the binding partner of CCAR2 from SENP1 to PIAS3. / Acetylation at Lys-112 and Lys-215 by KAT8 prevents inhibitory binding to SIRT1 and increases its deacetylase activity. / Genotoxic stress induces its sumoylation and sumoylation promotes the SIRT1-CCAR2 interaction which in turn inhibits SIRT1-mediated deacetylation of p53/TP53. Sumoylation leads to transcriptional activation of p53/TP53 by sequestering SIRT1 from p53/TP53. Desumoylated by SENP1.
|Protein cellular localization|| |
Nucleus / Cytoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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