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Mouse Monoclonal DDR1 antibody [2G4E12] (STJ97996)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
DDR1 antibody, CAK antibody, EDDR1 antibody, NEP antibody, NTRK4 antibody, PTK3A antibody, RTK6 antibody, TRKE antibody,|CAK antibody|CD 167 antibody|CD167 antibody|CD167 antigen-like family member A antibody|CD167a antibody|Cell adhesion kinase antibody|DDR 1 antibody|DDR antibody|DDR1 antibody|DDR1_HUMAN antibody|Discoidin domain receptor antibody|Discoidin domain receptor tyrosine kinase 1 antibody|Discoidin receptor tyrosine kinase antibody|Discoidin receptor tyrosine kinase isoform a antibody|EDDR 1 antibody|EDDR1 antibody|Epithelial discoidin domain receptor 1 antibody|Epithelial discoidin domain-containing receptor 1 antibody|Epithelial specific receptor kinase antibody|HGK2 antibody|Mammarian carcinoma kinase 10 antibody|Mammary carcinoma kinase 10 antibody|MCK-10 antibody|MCK10 antibody|NEP antibody|Neuroepithelial tyrosine kinase antibody|Neurotrophic tyrosine kinase receptor type 4 antibody|NTRK 4 antibody|NTRK4 antibody|OTTHUMP00000029343 antibody|OTTHUMP00000029344 antibody|OTTHUMP00000029345 antibody|OTTHUMP00000029346 antibody|OTTHUMP00000029347 antibody|OTTHUMP00000164863 antibody|OTTHUMP00000164867 antibody|OTTHUMP00000222080 antibody|Protein-tyrosine kinase 3A antibody|Protein-tyrosine kinase RTK-6 antibody|PTK 3 antibody|PTK 3A protein tyrosine kinase 3A antibody|PTK3 antibody|PTK3A antibody|Receptor tyrosine kinase NEP antibody|RTK 6 antibody|RTK6 antibody|TRK E antibody|TRKE antibody|Tyrosine kinase DDR antibody|Tyrosine kinase receptor E antibody|Tyrosine-protein kinase CAK antibody|Anti-MCK10 antibody (ab135643)
SCBT cat No: sc-21790|sc-532|sc-374618|sc-390268|sc-8988|sc-7553|
DDR1 Monoclonal Antibody
|Catalogue No.|| |
DDR1 Monoclonal Antibody detects endogenous levels of DDR1 protein.
Purified recombinant fragment of DDR1 (aa602-681) expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
DDR1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
DDR1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Epithelial discoidin domain-containing receptor 1 antibody, Epithelial discoidin domain receptor 1 antibody, CD167 antigen-like family member A antibody, Cell adhesion kinase antibody, Discoidin receptor tyrosine kinase antibody, HGK2 antibody, Mammary carcinoma kinase 10 antibody, MCK-10 antibody, Protein-tyrosine kinase 3A antibody, Protein-tyrosine kinase RTK-6 antibody, TRK E antibody, Tyrosine kinase DDR antibody, Tyrosine-protein kinase CAK antibody, CD antigen CD167a antibody
|Protein names|| |
Epithelial discoidin domain-containing receptor 1 , Epithelial discoidin domain receptor 1 , CD167 antigen-like family member A , Cell adhesion kinase , Discoidin receptor tyrosine kinase , HGK2 , Mammary carcinoma kinase 10 , MCK-10 , Protein-tyrosine kinase 3A , Protein-tyrosine kinase RTK-6 , TRK E , Tyrosine kinase DDR , Tyrosine-protein kinase CAK , CD antigen CD167a
|Protein function|| |
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. / Inhibited by the multi-targeted cancer drugs imatinib and ponatinib.
|Protein tissue specificity|| |
Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin.
|Protein sequence and domain|| |
The Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand or substrates. / Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. / Contains 1 F5/8 type C domain. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Autophosphorylated in response to fibrillar collagen binding. / Glycosylation of Asn-211, but apparently not of Asn-260, Asn-371, or Asn-394, prevents autophosphorylation from occurring in the absence of collagen.
|Protein cellular localization|| |
Cell membrane; Single-pass type I membrane protein / Cell membrane; Single-pass type I membrane protein / Secreted / Cell membrane; Single-pass type I membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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