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Mouse Monoclonal DDR2 antibody [3B11E4] (STJ97997)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
DDR2 antibody, NTRKR3 antibody, TKT antibody, TYRO10 antibody,|CD167 antigen-like family member B antibody|Tyrosine protein kinase TYRO 10 antibody|Tyrosine protein kinase TYRO10 antibody|Tyrosine-protein kinase TYRO10 antibody|Tyrosylprotein kinase antibody|Anti-DDR2 antibody (ab76967)
SCBT cat No: sc-81707|sc-8989|sc-7555|
DDR2 Monoclonal Antibody
|Catalogue No.|| |
DDR2 Monoclonal Antibody detects endogenous levels of DDR2 protein.
Purified recombinant fragment of human DDR2 expressed in E Coli
WB, IHC, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000
DDR2 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
DDR2 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Discoidin domain-containing receptor 2 antibody, Discoidin domain receptor 2 antibody, CD167 antigen-like family member B antibody, Discoidin domain-containing receptor tyrosine kinase 2 antibody, Neurotrophic tyrosine kinase, receptor-related 3 antibody, Receptor protein-tyrosine kinase TKT antibody, Tyrosine-protein kinase TYRO10 antibody, CD antigen CD167b antibody
|Protein names|| |
Discoidin domain-containing receptor 2 , Discoidin domain receptor 2 , CD167 antigen-like family member B , Discoidin domain-containing receptor tyrosine kinase 2 , Neurotrophic tyrosine kinase, receptor-related 3 , Receptor protein-tyrosine kinase TKT , Tyrosine-protein kinase TYRO10 , CD antigen CD167b
|Protein function|| |
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. / Present in an inactive state in the absence of collagen binding and phosphorylation by SRC. Tyrosine phosphorylation enhances the affinity for ATP and the catalytic activity.
|Protein tissue specificity|| |
Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney.
|Involvement in disease|| |
Spondyloepimetaphyseal dysplasia short limb-hand type (SEMD-SL) [MIM:271665]: A bone disease characterized by short-limbed dwarfism, a narrow chest with pectus excavatum, brachydactyly in the hands and feet, a characteristic craniofacial appearance and premature calcifications. The radiological findings are distinctive and comprise short long bones throughout the skeleton with striking epiphyses that are stippled, flattened and fragmented and flared, irregular metaphyses. Platyspondyly in the spine with wide intervertebral spaces is observed and some vertebral bodies are pear-shaped with central humps, anterior protrusions and posterior scalloping. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. / Contains 1 F5/8 type C domain. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
N-glycosylated. / Tyrosine phosphorylated in response to collagen binding. Phosphorylated by SRC; this is required for activation and subsequent autophosphorylation on additional tyrosine residues.
|Protein cellular localization|| |
Cell membrane / Single-pass type I membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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