Mouse Monoclonal DDR2 antibody [3B11E4] (STJ97997)

$379.00

Reactivity: Human
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal DDR2 antibody [3B11E4] (STJ97997)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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DDR2 antibody, NTRKR3 antibody, TKT antibody, TYRO10 antibody,|CD167 antigen-like family member B antibody|Tyrosine protein kinase TYRO 10 antibody|Tyrosine protein kinase TYRO10 antibody|Tyrosine-protein kinase TYRO10 antibody|Tyrosylprotein kinase antibody|Anti-DDR2 antibody (ab76967)
SCBT cat No: sc-81707|sc-8989|sc-7555|

 

Name

DDR2 Monoclonal Antibody

Catalogue No.

STJ97997

Reactivity

Human

Specificity

DDR2 Monoclonal Antibody detects endogenous levels of DDR2 protein.

Immunogen

Purified recombinant fragment of human DDR2 expressed in E Coli

Host

Mouse

Applications

WB, IHC, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG2a

Formulation

DDR2 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

DDR2 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Discoidin domain-containing receptor 2 antibody, Discoidin domain receptor 2 antibody, CD167 antigen-like family member B antibody, Discoidin domain-containing receptor tyrosine kinase 2 antibody, Neurotrophic tyrosine kinase, receptor-related 3 antibody, Receptor protein-tyrosine kinase TKT antibody, Tyrosine-protein kinase TYRO10 antibody, CD antigen CD167b antibody

Database links

Human UniProt/Swiss-Prot:Q16832;Mouse UniPort/Swiss-Prot: Q62371;Rat UniProt/Swiss-Port: B1WC09;Human Entrez Gene: 4921;Mouse Entrez Gene: 18214;Rat Entrez Gene: Rn.224678

Protein names

Discoidin domain-containing receptor 2 , Discoidin domain receptor 2 , CD167 antigen-like family member B , Discoidin domain-containing receptor tyrosine kinase 2 , Neurotrophic tyrosine kinase, receptor-related 3 , Receptor protein-tyrosine kinase TKT , Tyrosine-protein kinase TYRO10 , CD antigen CD167b

Protein function

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. / Present in an inactive state in the absence of collagen binding and phosphorylation by SRC. Tyrosine phosphorylation enhances the affinity for ATP and the catalytic activity.

Protein tissue specificity

Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney.

Involvement in disease

Spondyloepimetaphyseal dysplasia short limb-hand type (SEMD-SL) [MIM:271665]: A bone disease characterized by short-limbed dwarfism, a narrow chest with pectus excavatum, brachydactyly in the hands and feet, a characteristic craniofacial appearance and premature calcifications. The radiological findings are distinctive and comprise short long bones throughout the skeleton with striking epiphyses that are stippled, flattened and fragmented and flared, irregular metaphyses. Platyspondyly in the spine with wide intervertebral spaces is observed and some vertebral bodies are pear-shaped with central humps, anterior protrusions and posterior scalloping. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. / Contains 1 F5/8 type C domain. / Contains 1 protein kinase domain.

Protein post-translational modifications

N-glycosylated. / Tyrosine phosphorylated in response to collagen binding. Phosphorylated by SRC; this is required for activation and subsequent autophosphorylation on additional tyrosine residues.

Protein cellular localization

Cell membrane / Single-pass type I membrane protein

Research area

All research areas>Membrane Receptors>DDR
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize DDR2 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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