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Mouse Monoclonal Dynactin 1 antibody (STJ98487)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF
Recommended dilution: WB 1:1000-1:2000; IF 1:100-1:500
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
DCTN1 antibody,|150 kDa dynein associated polypeptide antibody|150 kDa dynein-associated polypeptide antibody|DAP 150 antibody|DAP-150 antibody|DAP150 antibody|DCTN 1 antibody|DCTN1 antibody|DCTN1_HUMAN antibody|DP 150 antibody|DP-150 antibody|DP150 antibody|Dynactin 1 (p150 Glued (Drosophila) homolog) antibody|Dynactin 1 (p150 glued homolog Drosophila) antibody|Dynactin 1 antibody|Dynactin subunit 1 antibody|Dynactin1 antibody|HMN7B antibody|p135 antibody|p150 Glued (Drosophila) homolog antibody|p150 glued antibody|p150 glued homolog antibody|p150(GLUED) DROSOPHILA HOMOLOG OF antibody|p150-glued antibody|p150glued antibody|Anti-DCTN1 antibody (ab11806)
SCBT cat No: sc-365274|sc-365054|sc-9801|sc-271166|sc-11363|sc-167697|sc-393389|
Dynactin 1 Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Cow, Pig
Dynactin 1 Monoclonal Antibody detects endogenous levels of Dynactin 1 protein.
Purified recombinant human Dynactin 1 protein fragments expressed in Ecoli
|Recommended dilution|| |
WB 1:1000-1:2000; IF 1:100-1:500
Dynactin 1 Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
Dynactin 1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Dynactin subunit 1 antibody, 150 kDa dynein-associated polypeptide antibody, DAP-150 antibody, DP-150 antibody, p135 antibody, p150-glued antibody
|Protein names|| |
Dynactin subunit 1 , 150 kDa dynein-associated polypeptide , DAP-150 , DP-150 , p135 , p150-glued
|Protein function|| |
Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
|Protein tissue specificity|| |
|Involvement in disease|| |
Neuronopathy, distal hereditary motor, 7B (HMN7B) [MIM:607641]: A neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Amyotrophic lateral sclerosis (ALS) [MIM:105400]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.; Perry syndrome (PERRYS) [MIM:168605]: A neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the dynactin 150 kDa subunit family. / Contains 1 CAP-Gly domain.
|Protein post-translational modifications|| |
Ubiquitinated by a SCF complex containing FBXL5, leading to its degradation by the proteasome. / Phosphorylation by SLK at Thr-145, Thr-146 and Thr-147 targets DCTN1 to the centrosome. It is uncertain if SLK phosphorylates all three threonines or one or two of them.
|Protein cellular localization|| |
Cytoplasm / Cytoplasm > cytoskeleton / Cytoplasm > cytoskeleton > microtubule organizing center > centrosome
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St John’s Laboratory Ltd.
|Product type|| |
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