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Mouse Monoclonal Dynamin II antibody [5E4C2F3] (STJ98005)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for Dynamin II Monoclonal Antibody.
Check alternative names for the antibodyExpand
DNM2 antibody, DYN2 antibody,|CMT2M antibody|CMTDI1 antibody|CMTDIB antibody|DI CMTB antibody|Dnm2 antibody|DYN II antibody|DYN2 antibody|DYN2_HUMAN antibody|Dynamin II antibody|Dynamin-2 antibody|Dynamin2 antibody|DynaminII antibody|DYNII antibody|Anti-Dynamin 2 antibody (ab3457)
SCBT cat No: sc-81150|sc-166526|sc-166525|sc-6400|sc-166669|
Dynamin II Monoclonal Antibody
|Catalogue No.|| |
Dynamin II Monoclonal Antibody detects endogenous levels of Dynamin II protein.
Purified recombinant fragment of Dynamin II expressed in E Coli
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Dynamin II Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Dynamin II Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
|Protein names|| |
|Protein function|| |
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis . Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). / GTP + H2O = GDP + phosphate.
|Protein tissue specificity|| |
|Involvement in disease|| |
Myopathy, centronuclear, 1 (CNM1) [MIM:160150]: A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Lethal congenital contracture syndrome 5 (LCCS5) [MIM:615368]: A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy and congenital non-progressive joint contractures. The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Charcot-Marie-Tooth disease, dominant, intermediate type, B (CMTDIB) [MIM:606482]: A form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. The dominant intermediate type B is characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Charcot-Marie-Tooth disease 2M (CMT2M) [MIM:606482]: An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. / Contains 1 dynamin-type G (guanine nucleotide-binding) domain. / Contains 1 GED domain. / Contains 1 PH domain.
|Protein post-translational modifications|| |
Phosphorylation at Ser-764 by CDK1 is greatly increased upon mitotic entry. It regulates cytokinesis downstream of calcineurin, and does not affect clathrin-mediated endocytosis. Dephosphorylated by calcineurin/PP2 (By similarity). Phosphorylated on tyrosine residues after activation of SRC (By similarity).
|Protein cellular localization|| |
Cytoplasm / Cytoplasm > cytoskeleton / Cell junction / Membrane > clathrin-coated pit / Cell junction > synapse > postsynaptic cell membrane > postsynaptic density / Cell junction > synapse / Midbody / Cell projection > phagocytic cup / Cytoplasmic vesicle > phagosome membrane / Peripheral membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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