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Mouse Monoclonal E-cadherin antibody [7H12] (STJ98009)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, FC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
CDH1 antibody, CDHE antibody, UVO antibody,|Arc 1 antibody|CADH1_HUMAN antibody|Cadherin 1 antibody|cadherin 1 type 1 E-cadherin antibody|Cadherin1 antibody|CAM 120/80 antibody|CD 324 antibody|CD324 antibody|CD324 antigen antibody|cdh1 antibody|CDHE antibody|E-Cad/CTF3 antibody|E-cadherin antibody|ECAD antibody|Epithelial cadherin antibody|epithelial calcium dependant adhesion protein antibody|LCAM antibody|Liver cell adhesion molecule antibody|UVO antibody|Uvomorulin antibody|Anti-E Cadherin antibody [HECD-1] (ab1416)
SCBT cat No: sc-71009|sc-71008|sc-71007|sc-52327|sc-21791|sc-52328|sc-59778|sc-8426|sc-7870|sc-31021|sc-59905|sc-1500|sc-31020|sc-59780|sc-56527|sc-137991|sc-376017|
E-cadherin Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Monkey
E-cadherin Monoclonal Antibody detects endogenous levels of E-cadherin protein.
Purified recombinant fragment of human E-cadherin expressed in E Coli
WB, IHC, FC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
E-cadherin Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
E-cadherin Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Cadherin-1 antibody, CAM 120/80 antibody, Epithelial cadherin antibody, E-cadherin antibody, Uvomorulin antibody, CD antigen CD324 antibody
|Protein names|| |
Cadherin-1 , CAM 120/80 , Epithelial cadherin , E-cadherin , Uvomorulin , CD antigen CD324
|Protein function|| |
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. / E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
|Protein tissue specificity|| |
Non-neural epithelial tissues.
|Involvement in disease|| |
Hereditary diffuse gastric cancer (HDGC) [MIM:137215]: A cancer predisposition syndrome with increased susceptibility to diffuse gastric cancer. Diffuse gastric cancer is a malignant disease characterized by poorly differentiated infiltrating lesions resulting in thickening of the stomach. Malignant tumors start in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Heterozygous CDH1 germline mutations are responsible for familial cases of diffuse gastric cancer. Somatic mutations has also been found in patients with sporadic diffuse gastric cancer and lobular breast cancer.; Endometrial cancer (ENDMC) [MIM:608089]: A malignancy of endometrium, the mucous lining of the uterus. Most endometrial cancers are adenocarcinomas, cancers that begin in cells that make and release mucus and other fluids. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.; Ovarian cancer (OC) [MIM:167000]: The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.; Breast cancer, lobular (LBC) [MIM:137215]: A type of breast cancer that begins in the milk-producing glands (lobules) of the breast. . Note: The gene represented in this entry may be involved in disease pathogenesis.
|Protein sequence and domain|| |
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. / Contains 5 cadherin domains.
|Protein post-translational modifications|| |
During apoptosis or with calcium influx, cleaved by a membrane-bound metalloproteinase (ADAM10), PS1/gamma-secretase and caspase-3 to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. Processing by the metalloproteinase, induced by calcium influx, causes disruption of cell-cell adhesion and the subsequent release of beta-catenin into the cytoplasm. The residual membrane-tethered cleavage product is rapidly degraded via an intracellular proteolytic pathway. Cleavage by caspase-3 releases the cytoplasmic tail resulting in disintegration of the actin microfilament system. The gamma-secretase-mediated cleavage promotes disassembly of adherens junctions. / N-glycosylation at Asn-637 is essential for expression, folding and trafficking. / Ubiquitinated by a SCF complex containing SKP2, which requires prior phosphorylation by CK1/CSNK1A1. Ubiquitinated by CBLL1/HAKAI, requires prior phosphorylation at Tyr-754.
|Protein cellular localization|| |
Cell junction / Cell membrane; Single-pass type I membrane protein / Endosome / Golgi apparatus > trans-Golgi network
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St John’s Laboratory Ltd.
|Product type|| |
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