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Mouse Monoclonal E2A antibody [6B8] (STJ98006)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, FC, ELISA
Recommended dilution: WB 1:500-1:2000; FC 1:200-1:400; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
TCF3 antibody, BHLHB21 antibody, E2A antibody, ITF1 antibody,|AGM8 antibody|bHLHb21 antibody|Class B basic helix-loop-helix protein 21 antibody|E12 antibody|E2A antibody|E2A immunoglobulin enhancer binding factors E12/E47 antibody|E47 antibody|Helix loop helix protein HE47 antibody|Immunoglobulin enhancer-binding factor E12/E47 antibody|Immunoglobulin transcription factor 1 antibody|ITF1 antibody|Kappa-E2-binding factor antibody|MGC129647 antibody|MGC129648 antibody|Negative vitamin D response element binding protein antibody|NOL1-TCF3 fusion antibody|TCF-3 antibody|Tcf3 antibody|TFE2_HUMAN antibody|transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) antibody|Transcription factor 3 antibody|transcription factor 3 variant 3 antibody|Transcription factor E2-alpha antibody|Transcription factor ITF-1 antibody|VDIR antibody|VDR interacting repressor antibody|vitamin D receptor-interacting repressor antibody|Anti-TCF3 / E2A antibody (ab69999)
SCBT cat No: sc-133074|sc-133075|sc-365261|sc-762|sc-763|sc-349|sc-416|
E2A Monoclonal Antibody
|Catalogue No.|| |
E2A Monoclonal Antibody detects endogenous levels of E2A protein.
Purified recombinant fragment of human E2A expressed in E Coli
WB, FC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; FC 1:200-1:400; ELISA 1:10000
E2A Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
E2A Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Transcription factor E2-alpha antibody, Class B basic helix-loop-helix protein 21 antibody, bHLHb21 antibody, Immunoglobulin enhancer-binding factor E12/E47 antibody, Immunoglobulin transcription factor 1 antibody, Kappa-E2-binding factor antibody, Transcription factor 3 antibody, TCF-3 antibody, Transcription factor ITF-1 antibody
|Protein names|| |
Transcription factor E2-alpha , Class B basic helix-loop-helix protein 21 , bHLHb21 , Immunoglobulin enhancer-binding factor E12/E47 , Immunoglobulin transcription factor 1 , Kappa-E2-binding factor , Transcription factor 3 , TCF-3 , Transcription factor ITF-1
|Protein function|| |
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5′-CANNTG-3′. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.
|Involvement in disease|| |
Note: Chromosomal aberrations involving TCF3 are cause of forms of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with PBX1. TCF3-PBX1 transforms cells by constitutively activating transcription of genes regulated by PBX1 or by other members of the PBX protein family (PubMed:1967983, PubMed:1671560). Translocation t(17;19)(q22;p13.3) with HLF (PubMed:1386162). Inversion inv(19)(p13;q13) with TFPT (PubMed:10086727). .
|Protein sequence and domain|| |
the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. / Contains 1 bHLH (basic helix-loop-helix) domain.
|Protein post-translational modifications|| |
Phosphorylated following NGF stimulation.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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