Mouse Monoclonal E2A antibody [6B8] (STJ98006)

$379.00

Reactivity: Human
Applications: WB, FC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal E2A antibody [6B8] (STJ98006)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, FC, ELISA

Recommended dilution: WB 1:500-1:2000; FC 1:200-1:400; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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TCF3 antibody, BHLHB21 antibody, E2A antibody, ITF1 antibody,|AGM8 antibody|bHLHb21 antibody|Class B basic helix-loop-helix protein 21 antibody|E12 antibody|E2A antibody|E2A immunoglobulin enhancer binding factors E12/E47 antibody|E47 antibody|Helix loop helix protein HE47 antibody|Immunoglobulin enhancer-binding factor E12/E47 antibody|Immunoglobulin transcription factor 1 antibody|ITF1 antibody|Kappa-E2-binding factor antibody|MGC129647 antibody|MGC129648 antibody|Negative vitamin D response element binding protein antibody|NOL1-TCF3 fusion antibody|TCF-3 antibody|Tcf3 antibody|TFE2_HUMAN antibody|transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) antibody|Transcription factor 3 antibody|transcription factor 3 variant 3 antibody|Transcription factor E2-alpha antibody|Transcription factor ITF-1 antibody|VDIR antibody|VDR interacting repressor antibody|vitamin D receptor-interacting repressor antibody|Anti-TCF3 / E2A antibody (ab69999)
SCBT cat No: sc-133074|sc-133075|sc-365261|sc-762|sc-763|sc-349|sc-416|

 

Name

E2A Monoclonal Antibody

Catalogue No.

STJ98006

Reactivity

Human

Specificity

E2A Monoclonal Antibody detects endogenous levels of E2A protein.

Immunogen

Purified recombinant fragment of human E2A expressed in E Coli

Host

Mouse

Applications

WB, FC, ELISA

Recommended dilution

WB 1:500-1:2000; FC 1:200-1:400; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

E2A Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

E2A Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Transcription factor E2-alpha antibody, Class B basic helix-loop-helix protein 21 antibody, bHLHb21 antibody, Immunoglobulin enhancer-binding factor E12/E47 antibody, Immunoglobulin transcription factor 1 antibody, Kappa-E2-binding factor antibody, Transcription factor 3 antibody, TCF-3 antibody, Transcription factor ITF-1 antibody

Database links

Human UniProt/Swiss-Prot:P15923;Mouse UniPort/Swiss-Prot: P15806;Rat UniProt/Swiss-Port: P21677;Human Entrez Gene: 6929;Mouse Entrez Gene: 21423;Rat Entrez Gene: Rn.10290

Protein names

Transcription factor E2-alpha , Class B basic helix-loop-helix protein 21 , bHLHb21 , Immunoglobulin enhancer-binding factor E12/E47 , Immunoglobulin transcription factor 1 , Kappa-E2-binding factor , Transcription factor 3 , TCF-3 , Transcription factor ITF-1

Protein function

Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5′-CANNTG-3′. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.

Involvement in disease

Note: Chromosomal aberrations involving TCF3 are cause of forms of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with PBX1. TCF3-PBX1 transforms cells by constitutively activating transcription of genes regulated by PBX1 or by other members of the PBX protein family (PubMed:1967983, PubMed:1671560). Translocation t(17;19)(q22;p13.3) with HLF (PubMed:1386162). Inversion inv(19)(p13;q13) with TFPT (PubMed:10086727). .

Protein sequence and domain

the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. / Contains 1 bHLH (basic helix-loop-helix) domain.

Protein post-translational modifications

Phosphorylated following NGF stimulation.

Protein cellular localization

Nucleus

Research area

All research areas>Transcription Regulators>E
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize E2A Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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