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Mouse Monoclonal EHMT1 antibody [1B7B4] (STJ98015)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
EHMT1 antibody, EUHMTASE1 antibody, GLP antibody, KIAA1876 antibody, KMT1D antibody,|bA188C12.1 antibody|DKFZp667M072 antibody|EHMT 1 antibody|EHMT1 antibody|EHMT1_HUMAN antibody|Eu-HMTase1 antibody|Euchromatic histone lysine N methyltransferase 1 antibody|Euchromatic histone methyltransferase 1 antibody|Euchromatic histone-lysine N-methyltransferase 1 antibody|EUHMTASE1 antibody|FLJ12879 antibody|FP13812 antibody|G9a like protein 1 antibody|G9a like protein antibody|G9a-like protein 1 antibody|GLP 1 antibody|GLP antibody|GLP1 antibody|H3 K9 HMTase 5 antibody|H3-K9-HMTase 5 antibody|Histone H3 K9 methyltransferase 5 antibody|Histone H3-K9 methyltransferase 5 antibody|Histone lysine N methyltransferase H3 lysine 9 specific 5 antibody|Histone-lysine N-methyltransferase EHMT1 antibody|KIAA1876 antibody|Lysine N methyltransferase 1D antibody|Lysine N-methyltransferase 1D antibody|RP11 188C12.1 antibody|Anti-EHMT1/GLP antibody [B0422] – ChIP Grade (ab41969)
SCBT cat No: sc-68165|sc-130747|sc-68166|
EHMT1 Monoclonal Antibody
|Catalogue No.|| |
EHMT1 Monoclonal Antibody detects endogenous levels of EHMT1 protein.
Purified recombinant fragment of EHMT1 expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
EHMT1 Antibody was tube-contained. Purified antibody in PBS containing 0.03% sodium azide.
EHMT1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Histone-lysine N-methyltransferase EHMT1 antibody, Euchromatic histone-lysine N-methyltransferase 1 antibody, Eu-HMTase1 antibody, G9a-like protein 1 antibody, GLP antibody, GLP1 antibody, Histone H3-K9 methyltransferase 5 antibody, H3-K9-HMTase 5 antibody, Lysine N-methyltransferase 1D antibody
|Protein names|| |
Histone-lysine N-methyltransferase EHMT1 , Euchromatic histone-lysine N-methyltransferase 1 , Eu-HMTase1 , G9a-like protein 1 , GLP , GLP1 , Histone H3-K9 methyltransferase 5 , H3-K9-HMTase 5 , Lysine N-methyltransferase 1D
|Protein function|| |
Histone methyltransferase that specifically mono- and dimethylates ‘Lys-9’ of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates ‘Lys-27’ of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of ‘Lys-373’ of p53/TP53. / S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. / Methyltransferase activity is inhibited by BIX-01294. Efficiently inhibited by compound E72, a BIX-01294 derivative in which the diazepane ring and the benzyl are replaced with a 3-dimethylaminopropyl and a 5-aminopentyl group at sites B and C, respectively.
|Protein tissue specificity|| |
|Involvement in disease|| |
Kleefstra syndrome (KLESTS) [MIM:610253]: A syndrome characterized by severe mental retardation, hypotonia, brachy(micro)cephaly, and facial dysmorphisms. Additionally, congenital heart defects, urogenital defects, epilepsy and behavioral problems are frequently observed. . Note: The disease is caused by mutations affecting the gene represented in this entry (PubMed:16826528). The syndrome can be either caused by intragenic EHMT1 mutations leading to haploinsufficiency of the EHMT1 gene or by a submicroscopic 9q34.3 deletion. Although it is not known if and to what extent other genes in the 9q34.3 region contribute to the syndrome observed in deletion cases, EHMT1 seems to be the major determinant of the core disease phenotype (PubMed:19264732). .
|Protein sequence and domain|| |
The ANK repeats recognize and bind RELA subunit of NF-kappa-B, when RELA is monomethylated at ‘Lys-310’ (By similarity). They also specifically recognize and bind H3K9me1 and H3K9me2. / The SET domain mediates interaction with WIZ. / In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster. / Belongs to the class V-like SAM-binding methyltransferase superfamily. / Contains 8 ANK repeats. / Contains 1 pre-SET domain. / Contains 1 SET domain.
|Protein cellular localization|| |
Nucleus / Chromosome
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St John’s Laboratory Ltd.
|Product type|| |
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