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Mouse Monoclonal eIF4E antibody [5D11] (STJ98016)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, FC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
EIF4E antibody, EIF4EL1 antibody, EIF4F antibody,|AUTS19 antibody|CBP antibody|eIF 4E antibody|eIF 4F 25 kDa subunit antibody|EIF 4F antibody|eIF-4E antibody|eIF-4F 25 kDa subunit antibody|eIF4E antibody|EIF4E1 antibody|EIF4EL1 antibody|EIF4F antibody|Eukaryotic translation initiation factor 4 E antibody|Eukaryotic translation initiation factor 4E antibody|Eukaryotic translation initiation factor 4E like 1 antibody|IF4E_HUMAN antibody|Messanger RNA Cap Binding Protein eIF 4E antibody|MGC111573 antibody|mRNA cap binding protein antibody|mRNA cap-binding protein antibody|Phospho anti-eIF4E (S209) antibody [EP2151Y] (ab76256)
SCBT cat No: sc-271480|sc-6968|sc-514875|sc-13963|sc-9976|sc-100731|
eIF4E Monoclonal Antibody
|Catalogue No.|| |
eIF4E Monoclonal Antibody detects endogenous levels of eIF4E protein.
Purified recombinant fragment of human eIF4E expressed in E Coli
WB, IHC, IF, FC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
eIF4E Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
eIF4E Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Eukaryotic translation initiation factor 4E antibody, eIF-4E antibody, eIF4E antibody, eIF-4F 25 kDa subunit antibody, mRNA cap-binding protein antibody
|Protein names|| |
Eukaryotic translation initiation factor 4E , eIF-4E , eIF4E , eIF-4F 25 kDa subunit , mRNA cap-binding protein
|Protein function|| |
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.
|Involvement in disease|| |
Autism 19 (AUTS19) [MIM:615091]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. A heterozygous single-nucleotide insertion has been found in families affected by autism. The variant results in increased promoter activity and is involved in disease pathogenesis through EIF4E deregulation (PubMed:19556253). .; Note: A chromosomal aberration involving EIF4E has been found in a patient with classic autism. Translocation t(45)(q23q31.3). The breakpoint on chromosome 4 is located 56 kb downstream of EIF4E (PubMed:19556253). .
|Protein sequence and domain|| |
Belongs to the eukaryotic initiation factor 4E family.
|Protein post-translational modifications|| |
Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.
|Protein cellular localization|| |
Cytoplasm > P-body / Cytoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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