Mouse Monoclonal Elk1 antibody [7E10D5; 7E10E8] (STJ98018)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Elk1 antibody [7E10D5; 7E10E8] (STJ98018)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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ELK1 antibody,|ELK 1 antibody|Elk1 antibody|ELK1 member of ETS oncogene family antibody|ELK1 protein antibody|ELK1_HUMAN antibody|ELK2 member of ETS oncogene family antibody|ETS domain containing protein Elk 1 antibody|ETS domain containing protein Elk1 antibody|ETS domain protein Elk1 antibody|ETS domain-containing protein Elk-1 antibody|ETS like gene 1 antibody|Member of ETS oncogene family antibody|Oncogene Elk1 antibody|Tyrosine kinase (ELK1) oncogene antibody|Anti-ELK1 antibody [E277] – ChIP Grade (ab32106)
SCBT cat No: sc-65986|sc-365876|sc-22804|sc-355|sc-365715|sc-515041|sc-81264|sc-398959|

 

Name

Elk1 Monoclonal Antibody

Catalogue No.

STJ98018

Reactivity

Human

Specificity

Elk1 Monoclonal Antibody detects endogenous levels of Elk1 protein.

Immunogen

Purified recombinant fragment of Elk1 expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

Elk1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

Elk1 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

ETS domain-containing protein Elk-1 antibody

Database links

Human UniProt/Swiss-Prot:P19419;Mouse UniPort/Swiss-Prot: P41969;Rat UniProt/Swiss-Port: A4GTP4;Human Entrez Gene: 2002;Mouse Entrez Gene: 13712;Rat Entrez Gene: Rn.203416

Protein names

ETS domain-containing protein Elk-1

Protein function

Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity).

Protein tissue specificity

Lung and testis.

Protein sequence and domain

Belongs to the ETS family. / Contains 1 ETS DNA-binding domain.

Protein post-translational modifications

Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention. / On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Also phosphorylated on Ser-383 by MAPK8 and/or MAKP9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CAMK4, MAPK11, MAPK12 and MAPK14. Upon bFGF stimulus, phosphorylated by PAK1 (By similarity).

Protein cellular localization

Nucleus

Research area

All research areas>Transcription Regulators>Elf
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize Elk1 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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