Mouse Monoclonal EP-CAM antibody (STJ98490)

$379.00

Reactivity: Human, Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal EP-CAM antibody (STJ98490)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB

Recommended dilution: WB 1:1000-1:2000

Recommended protocols: check protocols

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Alternative names:

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EPCAM antibody, GA733-2 antibody, M1S2 antibody, M4S1 antibody, MIC18 antibody, TACSTD1 antibody, TROP1 antibody,|17 1A antibody|323/A3 antibody|Adenocarcinoma associated antigen antibody|Adenocarcinoma-associated antigen antibody|Antigen identified by monoclonal antibody AUA1 antibody|AUA1 antibody|CD326 antibody|CD326 antigen antibody|Cell surface glycoprotein Trop 1 antibody|Cell surface glycoprotein Trop 2 antibody|Cell surface glycoprotein Trop-1 antibody|CO 17A antibody|CO17 1A antibody|CO17A antibody|DIAR5 antibody|EGP 2 antibody|EGP antibody|EGP2 antibody|EGP314 antibody|EGP40 antibody|Ep CAM antibody|Ep-CAM antibody|EPCAM antibody|EPCAM_HUMAN antibody|EpCAM1 antibody|Epithelial cell adhesion molecule antibody|Epithelial Cell Adhesion Molecule Intracellular Domain (EpCAM-ICD) antibody|Epithelial cell surface antigen antibody|Epithelial cellular adhesion molecule antibody|Epithelial glycoprotein 1 antibody|Epithelial glycoprotein 314 antibody|Epithelial glycoprotein antibody|ESA antibody|GA733 1 antibody|GA733 2 antibody|GA733-2 antibody|gastrointestinal tumor-associated antigen 2, 35-KD glycoprotein antibody|gp4 antibody|hEGP 2 antibody|hEGP314 antibody|HNPCC8 antibody|Human epithelial glycoprotein 2 antibody|KS 1/4 antigen antibody|KS1/4 antibody|KSA antibody|Ly74 antibody|Lymphocyte antigen 74 antibody|M1S 1 antibody|M1S2 antibody|M4S1 antibody|Major gastrointestinal tumor associated protein GA733 2 antibody|Major gastrointestinal tumor-associated protein GA733-2 antibody|mEGP314 antibody|Membrane component chromosome 4 surface marker (35kD glycoprotein) antibody|Membrane component, chromosome 4, surface marker 1 antibody|Membrane component, chromosome 4, surface marker antibody|MIC18 antibody|MK 1 antibody|Protein 289A antibody|TACD1 antibody|TACSTD1 antibody|TROP1 antibody|Tumor associated calcium signal transducer 1 antibody|Tumor associated calcium signal transducer 2 precursor antibody|Tumor-associated calcium signal transducer 1 antibody|Anti-EpCAM antibody (ab71916)
SCBT cat No: sc-53532|

 

Name

EP-CAM Monoclonal Antibody

Catalogue No.

STJ98490

Reactivity

Human, Mouse

Specificity

EP-CAM Monoclonal Antibody detects endogenous levels of EP-CAM protein.

Immunogen

Purified recombinant human EP-CAM (N-terminus) protein fragments expressed in Ecoli

Host

Mouse

Applications

WB

Recommended dilution

WB 1:1000-1:2000

Clonality

Monoclonal

Conjugation

Unconjugated

Formulation

EP-CAM Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Concentration

1 mg/ml

Purification

EP-CAM Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Epithelial cell adhesion molecule antibody, Ep-CAM antibody, Adenocarcinoma-associated antigen antibody, Cell surface glycoprotein Trop-1 antibody, Epithelial cell surface antigen antibody, Epithelial glycoprotein antibody, EGP antibody, Epithelial glycoprotein 314 antibody, EGP314 antibody, hEGP314 antibody, KS 1/4 antigen antibody, KSA antibody, Major gastrointestinal tumor-associated protein GA733-2 antibody, Tumor-associated calcium signal transducer 1 antibody, CD antigen CD326 antibody

Database links

Human UniProt/Swiss-Prot:P16422;Mouse UniPort/Swiss-Prot: Q99JW5;Rat UniProt/Swiss-Port: O55159;Human Entrez Gene: 4072;Mouse Entrez Gene: 17075;Rat Entrez Gene: Rn.106481

Protein names

Epithelial cell adhesion molecule , Ep-CAM , Adenocarcinoma-associated antigen , Cell surface glycoprotein Trop-1 , Epithelial cell surface antigen , Epithelial glycoprotein , EGP , Epithelial glycoprotein 314 , EGP314 , hEGP314 , KS 1/4 antigen , KSA , Major gastrointestinal tumor-associated protein GA733-2 , Tumor-associated calcium signal transducer 1 , CD antigen CD326

Protein function

May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.

Protein tissue specificity

Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC’s differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.

Involvement in disease

Diarrhea 5, with tufting enteropathy, congenital (DIAR5) [MIM:613217]: An intractable diarrhea of infancy characterized by villous atrophy and absence of inflammation, with intestinal epithelial cell dysplasia manifesting as focal epithelial tufts in the duodenum and jejunum. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Hereditary non-polyposis colorectal cancer 8 (HNPCC8) [MIM:613244]: An autosomal dominant disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early-onset colorectal carcinoma (CRC) and extra-colonic tumors of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world. Clinically, HNPCC is often divided into two subgroups. Type I is characterized by hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II is characterized by increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term ‘suspected HNPCC’ or ‘incomplete HNPCC’ can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected. . Note: The disease is caused by mutations affecting the gene represented in this entry. HNPCC8 results from heterozygous deletion of 3-prime exons of EPCAM and intergenic regions directly upstream of MSH2, resulting in transcriptional read-through and epigenetic silencing of MSH2 in tissues expressing EPCAM.

Protein sequence and domain

Belongs to the EPCAM family. / Contains 1 thyroglobulin type-1 domain.

Protein post-translational modifications

Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability.

Protein cellular localization

Lateral cell membrane / Single-pass type I membrane protein / Cell junction > tight junction

Research area

All research areas>Cell Adhesion Proteins>Ep-CAM
(View all antibody categories related to Cell Adhesion Proteins)

Note

AntibodyPlus can customize EP-CAM Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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