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Mouse Monoclonal EphA4 antibody [7D3D4] (STJ98026)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
EPHA4 antibody, HEK8 antibody, SEK antibody, TYRO1 antibody,|Cek 8 antibody|CEK8 antibody|EK8 antibody|eph receptor a4 antibody|EPH-like kinase 8 antibody|EPHA4 antibody|EPHA4_HUMAN antibody|Ephrin type-A receptor 4 antibody|HEK 8 antibody|hEK8 antibody|Receptor protein-tyrosine kinase HEK8 antibody|Sek 1 antibody|SEK antibody|TYRO 1 protein tyrosine kinase antibody|TYRO1 antibody|Tyrosine-protein kinase receptor SEK antibody|Tyrosine-protein kinase TYRO1 antibody|Anti-Eph receptor A4 antibody (ab5389)
SCBT cat No: sc-135897|sc-922|sc-25457|sc-921|
EphA4 Monoclonal Antibody
|Catalogue No.|| |
EphA4 Monoclonal Antibody detects endogenous levels of EphA4 protein.
Purified recombinant fragment of EphA4 (aa777-986) expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
EphA4 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
EphA4 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Ephrin type-A receptor 4 antibody, EPH-like kinase 8 antibody, EK8 antibody, hEK8 antibody, Tyrosine-protein kinase TYRO1 antibody, Tyrosine-protein kinase receptor SEK antibody
|Protein names|| |
Ephrin type-A receptor 4 , EPH-like kinase 8 , EK8 , hEK8 , Tyrosine-protein kinase TYRO1 , Tyrosine-protein kinase receptor SEK
|Protein function|| |
Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at ‘Tyr-15’ which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
|Protein tissue specificity|| |
|Protein sequence and domain|| |
The protein kinase domain mediates interaction with NGEF. / Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. / Contains 1 Eph LBD (Eph ligand-binding) domain. / Contains 2 fibronectin type-III domains. / Contains 1 protein kinase domain. / Contains 1 SAM (sterile alpha motif) domain.
|Protein cellular localization|| |
Cell membrane / Cell projection > axon / Cell projection > dendrite / Cell junction > synapse > postsynaptic cell membrane > postsynaptic density / Early endosome
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St John’s Laboratory Ltd.
|Product type|| |
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