Mouse Monoclonal EphA4 antibody [7D3D4] (STJ98026)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal EphA4 antibody [7D3D4] (STJ98026)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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EPHA4 antibody, HEK8 antibody, SEK antibody, TYRO1 antibody,|Cek 8 antibody|CEK8 antibody|EK8 antibody|eph receptor a4 antibody|EPH-like kinase 8 antibody|EPHA4 antibody|EPHA4_HUMAN antibody|Ephrin type-A receptor 4 antibody|HEK 8 antibody|hEK8 antibody|Receptor protein-tyrosine kinase HEK8 antibody|Sek 1 antibody|SEK antibody|TYRO 1 protein tyrosine kinase antibody|TYRO1 antibody|Tyrosine-protein kinase receptor SEK antibody|Tyrosine-protein kinase TYRO1 antibody|Anti-Eph receptor A4 antibody (ab5389)
SCBT cat No: sc-135897|sc-922|sc-25457|sc-921|

 

Name

EphA4 Monoclonal Antibody

Catalogue No.

STJ98026

Reactivity

Human

Specificity

EphA4 Monoclonal Antibody detects endogenous levels of EphA4 protein.

Immunogen

Purified recombinant fragment of EphA4 (aa777-986) expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

EphA4 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

EphA4 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Ephrin type-A receptor 4 antibody, EPH-like kinase 8 antibody, EK8 antibody, hEK8 antibody, Tyrosine-protein kinase TYRO1 antibody, Tyrosine-protein kinase receptor SEK antibody

Database links

Human UniProt/Swiss-Prot:P54764;Mouse UniPort/Swiss-Prot: Q03137;Rat UniProt/Swiss-Port: D3ZZK3;Human Entrez Gene: 2043;Mouse Entrez Gene: 13838;Rat Entrez Gene: Rn.6202

Protein names

Ephrin type-A receptor 4 , EPH-like kinase 8 , EK8 , hEK8 , Tyrosine-protein kinase TYRO1 , Tyrosine-protein kinase receptor SEK

Protein function

Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at ‘Tyr-15’ which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

The protein kinase domain mediates interaction with NGEF. / Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. / Contains 1 Eph LBD (Eph ligand-binding) domain. / Contains 2 fibronectin type-III domains. / Contains 1 protein kinase domain. / Contains 1 SAM (sterile alpha motif) domain.

Protein cellular localization

Cell membrane / Cell projection > axon / Cell projection > dendrite / Cell junction > synapse > postsynaptic cell membrane > postsynaptic density / Early endosome

Research area

All research areas>Membrane Receptors>Eph
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize EphA4 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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