Mouse Monoclonal EphA5 antibody [8B10B1; 8B10F5] (STJ98027)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal EphA5 antibody [8B10B1; 8B10F5] (STJ98027)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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EPHA5 antibody, BSK antibody, EHK1 antibody, HEK7 antibody, TYRO4 antibody,|Brain-specific kinase antibody|bsk antibody|CEK 7 antibody|Eck like sequence 1 antibody|EHK 1 antibody|EHK-1 antibody|EK7 antibody|Els 1 antibody|EPH homology kinase 1 antibody|EPH-like kinase 7 antibody|EPHA5 antibody|EPHA5_HUMAN antibody|Ephrin type A receptor 5 antibody|Ephrin type-A receptor 5 antibody|HEK 7 antibody|hEK7 antibody|Receptor protein tyrosine kinase HEK 7 antibody|Rek 7 antibody|TYRO 4 antibody|Tyrosine protein kinase receptor EHK 1 antibody|Anti-Eph receptor A5 antibody (ab5397)
SCBT cat No: sc-927|sc-25458|sc-1014|

 

Name

EphA5 Monoclonal Antibody

Catalogue No.

STJ98027

Reactivity

Human

Specificity

EphA5 Monoclonal Antibody detects endogenous levels of EphA5 protein.

Immunogen

Purified recombinant fragment of EphA5 (aa620-774) expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

EphA5 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

EphA5 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Ephrin type-A receptor 5 antibody, Brain-specific kinase antibody, EPH homology kinase 1 antibody, EHK-1 antibody, EPH-like kinase 7 antibody, EK7 antibody, hEK7 antibody

Database links

Human UniProt/Swiss-Prot:P54756;Mouse UniPort/Swiss-Prot: Q60629;Rat UniProt/Swiss-Port: F1M7W0;Human Entrez Gene: 2044;Mouse Entrez Gene: 13839;Rat Entrez Gene: Rn.24569

Protein names

Ephrin type-A receptor 5 , Brain-specific kinase , EPH homology kinase 1 , EHK-1 , EPH-like kinase 7 , EK7 , hEK7

Protein function

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity). / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Protein tissue specificity

Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord.

Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. / Contains 1 Eph LBD (Eph ligand-binding) domain. / Contains 2 fibronectin type-III domains. / Contains 1 protein kinase domain. / Contains 1 SAM (sterile alpha motif) domain.

Protein post-translational modifications

Phosphorylated. Phosphorylation is stimulated by the ligand EFNA5. Dephosphorylation upon stimulation by glucose, inhibits EPHA5 forward signaling and results in insulin secretion (By similarity).

Protein cellular localization

Cell membrane / Single-pass type I membrane protein / Cell projection > axon / Cell projection > dendrite

Research area

All research areas>Membrane Receptors>Eph
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize EphA5 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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