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Mouse Monoclonal EphA5 antibody [8B10B1; 8B10F5] (STJ98027)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
EPHA5 antibody, BSK antibody, EHK1 antibody, HEK7 antibody, TYRO4 antibody,|Brain-specific kinase antibody|bsk antibody|CEK 7 antibody|Eck like sequence 1 antibody|EHK 1 antibody|EHK-1 antibody|EK7 antibody|Els 1 antibody|EPH homology kinase 1 antibody|EPH-like kinase 7 antibody|EPHA5 antibody|EPHA5_HUMAN antibody|Ephrin type A receptor 5 antibody|Ephrin type-A receptor 5 antibody|HEK 7 antibody|hEK7 antibody|Receptor protein tyrosine kinase HEK 7 antibody|Rek 7 antibody|TYRO 4 antibody|Tyrosine protein kinase receptor EHK 1 antibody|Anti-Eph receptor A5 antibody (ab5397)
SCBT cat No: sc-927|sc-25458|sc-1014|
EphA5 Monoclonal Antibody
|Catalogue No.|| |
EphA5 Monoclonal Antibody detects endogenous levels of EphA5 protein.
Purified recombinant fragment of EphA5 (aa620-774) expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
EphA5 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
EphA5 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Ephrin type-A receptor 5 antibody, Brain-specific kinase antibody, EPH homology kinase 1 antibody, EHK-1 antibody, EPH-like kinase 7 antibody, EK7 antibody, hEK7 antibody
|Protein names|| |
Ephrin type-A receptor 5 , Brain-specific kinase , EPH homology kinase 1 , EHK-1 , EPH-like kinase 7 , EK7 , hEK7
|Protein function|| |
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity). / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
|Protein tissue specificity|| |
Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. / Contains 1 Eph LBD (Eph ligand-binding) domain. / Contains 2 fibronectin type-III domains. / Contains 1 protein kinase domain. / Contains 1 SAM (sterile alpha motif) domain.
|Protein post-translational modifications|| |
Phosphorylated. Phosphorylation is stimulated by the ligand EFNA5. Dephosphorylation upon stimulation by glucose, inhibits EPHA5 forward signaling and results in insulin secretion (By similarity).
|Protein cellular localization|| |
Cell membrane / Single-pass type I membrane protein / Cell projection > axon / Cell projection > dendrite
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St John’s Laboratory Ltd.
|Product type|| |
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