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Mouse Monoclonal EphA8 antibody [9A12D8] (STJ98030)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for EphA8 Monoclonal Antibody.
Check alternative names for the antibodyExpand
EPHA8 antibody, EEK antibody, HEK3 antibody, KIAA1459 antibody,||
SCBT cat No: To be updated
EphA8 Monoclonal Antibody
|Catalogue No.|| |
EphA8 Monoclonal Antibody detects endogenous levels of EphA8 protein.
Purified recombinant fragment of EphA8 (aa70-150) expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
EphA8 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
EphA8 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Ephrin type-A receptor 8 antibody, EPH- and ELK-related kinase antibody, EPH-like kinase 3 antibody, EK3 antibody, hEK3 antibody, Tyrosine-protein kinase receptor EEK antibody
|Protein names|| |
Ephrin type-A receptor 8 , EPH- and ELK-related kinase , EPH-like kinase 3 , EK3 , hEK3 , Tyrosine-protein kinase receptor EEK
|Protein function|| |
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. / Contains 1 Eph LBD (Eph ligand-binding) domain. / Contains 2 fibronectin type-III domains. / Contains 1 protein kinase domain. / Contains 1 SAM (sterile alpha motif) domain.
|Protein post-translational modifications|| |
Phosphorylated. Phosphorylation is stimulated upon binding of its ligands including EFNA2, EFNA3 and EFNA5. Autophosphorylation on Tyr-616 is critical for association with FYN. Autophosphorylation on Tyr-839 modulates tyrosine kinase activity (By similarity). / Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation. ANKS1A prevents ubiquitination and degradation (By similarity).
|Protein cellular localization|| |
Cell membrane / Single-pass type I membrane protein / Cell projection / Early endosome membrane
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St John’s Laboratory Ltd.
|Product type|| |
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