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Mouse Monoclonal EphB1 antibody [5F10A4] (STJ98031)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
EPHB1 antibody, ELK antibody, EPHT2 antibody, HEK6 antibody, NET antibody,|Cek 6 antibody|soluble EPHB1 variant 1 antibody|Tyrosine protein kinase receptor EPH 2 antibody|Tyrosine-protein kinase receptor EPH-2 antibody|Anti-Eph receptor B1 antibody [EPR6457] (ab129103)
SCBT cat No: sc-135718|
EphB1 Monoclonal Antibody
|Catalogue No.|| |
EphB1 Monoclonal Antibody detects endogenous levels of EphB1 protein.
Purified recombinant fragment of EphB1 (aa19-133) expressed in E Coli
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
EphB1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
EphB1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Ephrin type-B receptor 1 antibody, ELK antibody, EPH tyrosine kinase 2 antibody, EPH-like kinase 6 antibody, EK6 antibody, hEK6 antibody, Neuronally-expressed EPH-related tyrosine kinase antibody, NET antibody, Tyrosine-protein kinase receptor EPH-2 antibody
|Protein names|| |
Ephrin type-B receptor 1 , ELK , EPH tyrosine kinase 2 , EPH-like kinase 6 , EK6 , hEK6 , Neuronally-expressed EPH-related tyrosine kinase , NET , Tyrosine-protein kinase receptor EPH-2
|Protein function|| |
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
|Protein tissue specificity|| |
Preferentially expressed in brain.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. / Contains 1 Eph LBD (Eph ligand-binding) domain. / Contains 2 fibronectin type-III domains. / Contains 1 protein kinase domain. / Contains 1 SAM (sterile alpha motif) domain.
|Protein post-translational modifications|| |
Phosphorylated. Autophosphorylation is stimulated by the ligand EFNB1. Required for interaction with SH2 domain-containing interactors, for activation of the MAPK/ERK and JUN signaling cascades and for ubiquitination by CBL. / Ubiquitinated; (EFNB1)ligand-induced poly- and/or multi-ubiquitination by CBL is regulated by SRC and leads to lysosomal degradation.
|Protein cellular localization|| |
Cell membrane / Single-pass type I membrane protein / Early endosome membrane / Cell projection > dendrite
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St John’s Laboratory Ltd.
|Product type|| |
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