Mouse Monoclonal EphB2 antibody [2D12C6] (STJ98032)

$379.00

Reactivity: Human
Applications: WB, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal EphB2 antibody [2D12C6] (STJ98032)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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EPHB2 antibody, DRT antibody, EPHT3 antibody, EPTH3 antibody, ERK antibody, HEK5 antibody, TYRO5 antibody,|cek5 antibody|DRT antibody|Eph receptor B2 antibody|EPH tyrosine kinase 3 antibody|EPH-like kinase 5 antibody|EPHB2 antibody|EPHB2_HUMAN antibody|Ephrin type B receptor 2 antibody|Ephrin type-B receptor 2 antibody|EPHT 3 antibody|ERK antibody|ETECK antibody|hEK5 antibody|Nuk antibody|Prkm 5 antibody|Receptor protein tyrosine kinase HEK 5 antibody|Renal carcinoma antigen NY-REN-47 antibody|Sek 3 antibody|Tyro 5 antibody|Tyrosine protein kinase receptor CEK 5 antibody|Tyrosine protein kinase receptor EPH 3 antibody|Tyrosine protein kinase receptor QEK 5 antibody|Tyrosine-protein kinase receptor EPH-3 antibody|Tyrosine-protein kinase TYRO5 antibody|Anti-Eph receptor B2 antibody (ab5418)
SCBT cat No: sc-130752|sc-27107|sc-1763|sc-28980|sc-100298|

 

Name

EphB2 Monoclonal Antibody

Catalogue No.

STJ98032

Reactivity

Human

Specificity

EphB2 Monoclonal Antibody detects endogenous levels of EphB2 protein.

Immunogen

Purified recombinant fragment of EphB2 (aa17-200) expressed in E Coli

Host

Mouse

Applications

WB, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG2b

Formulation

EphB2 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

EphB2 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Ephrin type-B receptor 2 antibody, Developmentally-regulated Eph-related tyrosine kinase antibody, ELK-related tyrosine kinase antibody, EPH tyrosine kinase 3 antibody, EPH-like kinase 5 antibody, EK5 antibody, hEK5 antibody, Renal carcinoma antigen NY-REN-47 antibody, Tyrosine-protein kinase TYRO5 antibody, Tyrosine-protein kinase receptor EPH-3 antibody

Database links

Human UniProt/Swiss-Prot:P29323;Mouse UniPort/Swiss-Prot: P54763;Rat UniProt/Swiss-Port: B2B9B0;Human Entrez Gene: 2048;Mouse Entrez Gene: 13844;Rat Entrez Gene: Rn.229866

Protein names

Ephrin type-B receptor 2 , Developmentally-regulated Eph-related tyrosine kinase , ELK-related tyrosine kinase , EPH tyrosine kinase 3 , EPH-like kinase 5 , EK5 , hEK5 , Renal carcinoma antigen NY-REN-47 , Tyrosine-protein kinase TYRO5 , Tyrosine-protein kinase receptor EPH-3

Protein function

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Protein tissue specificity

Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.

Involvement in disease

Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. . Note: The gene represented in this entry may be involved in disease pathogenesis. EPHB2 mutations have been found in a prostate cancer cell line derived from a brain metastasis.

Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. / Contains 1 Eph LBD (Eph ligand-binding) domain. / Contains 2 fibronectin type-III domains. / Contains 1 protein kinase domain. / Contains 1 SAM (sterile alpha motif) domain.

Protein cellular localization

Cell membrane; Single-pass type I membrane protein / Cell projection > axon / Cell projection > dendrite

Research area

All research areas>Membrane Receptors>Eph
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize EphB2 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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