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Mouse Monoclonal EphB2 antibody [2D12C6] (STJ98032)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
EPHB2 antibody, DRT antibody, EPHT3 antibody, EPTH3 antibody, ERK antibody, HEK5 antibody, TYRO5 antibody,|cek5 antibody|DRT antibody|Eph receptor B2 antibody|EPH tyrosine kinase 3 antibody|EPH-like kinase 5 antibody|EPHB2 antibody|EPHB2_HUMAN antibody|Ephrin type B receptor 2 antibody|Ephrin type-B receptor 2 antibody|EPHT 3 antibody|ERK antibody|ETECK antibody|hEK5 antibody|Nuk antibody|Prkm 5 antibody|Receptor protein tyrosine kinase HEK 5 antibody|Renal carcinoma antigen NY-REN-47 antibody|Sek 3 antibody|Tyro 5 antibody|Tyrosine protein kinase receptor CEK 5 antibody|Tyrosine protein kinase receptor EPH 3 antibody|Tyrosine protein kinase receptor QEK 5 antibody|Tyrosine-protein kinase receptor EPH-3 antibody|Tyrosine-protein kinase TYRO5 antibody|Anti-Eph receptor B2 antibody (ab5418)
SCBT cat No: sc-130752|sc-27107|sc-1763|sc-28980|sc-100298|
EphB2 Monoclonal Antibody
|Catalogue No.|| |
EphB2 Monoclonal Antibody detects endogenous levels of EphB2 protein.
Purified recombinant fragment of EphB2 (aa17-200) expressed in E Coli
WB, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
EphB2 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
EphB2 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Ephrin type-B receptor 2 antibody, Developmentally-regulated Eph-related tyrosine kinase antibody, ELK-related tyrosine kinase antibody, EPH tyrosine kinase 3 antibody, EPH-like kinase 5 antibody, EK5 antibody, hEK5 antibody, Renal carcinoma antigen NY-REN-47 antibody, Tyrosine-protein kinase TYRO5 antibody, Tyrosine-protein kinase receptor EPH-3 antibody
|Protein names|| |
Ephrin type-B receptor 2 , Developmentally-regulated Eph-related tyrosine kinase , ELK-related tyrosine kinase , EPH tyrosine kinase 3 , EPH-like kinase 5 , EK5 , hEK5 , Renal carcinoma antigen NY-REN-47 , Tyrosine-protein kinase TYRO5 , Tyrosine-protein kinase receptor EPH-3
|Protein function|| |
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
|Protein tissue specificity|| |
Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.
|Involvement in disease|| |
Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. . Note: The gene represented in this entry may be involved in disease pathogenesis. EPHB2 mutations have been found in a prostate cancer cell line derived from a brain metastasis.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. / Contains 1 Eph LBD (Eph ligand-binding) domain. / Contains 2 fibronectin type-III domains. / Contains 1 protein kinase domain. / Contains 1 SAM (sterile alpha motif) domain.
|Protein cellular localization|| |
Cell membrane; Single-pass type I membrane protein / Cell projection > axon / Cell projection > dendrite
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St John’s Laboratory Ltd.
|Product type|| |
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