Mouse Monoclonal EphB3 antibody [4A122D1] (STJ98033)


Reactivity: Human
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal EphB3 antibody [4A122D1] (STJ98033)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody


EPHB3 antibody, ETK2 antibody, HEK2 antibody, TYRO6 antibody,|Cek10 antibody|EK2 antibody|Embryonic kinase 2 antibody|EPH Like Tyrosine Kinase 2 antibody|EPH receptor B3 antibody|EPH-like kinase 2 antibody|ephb3 antibody|EPHB3_HUMAN antibody|Ephrin receptor EphB3 antibody|Ephrin type B receptor 3 antibody|Ephrin type-B receptor 3 antibody|ETK2 antibody|hEK2 antibody|Human Embryo Kinase 2 antibody|Mdk5 antibody|Sek4 antibody|TYRO6 antibody|Tyrosine protein kinase receptor HEK2 antibody|Tyrosine protein kinase TYRO6 antibody|Tyrosine-protein kinase TYRO6 antibody|Anti-Eph receptor B3 antibody [EPR8280] (ab133742)
SCBT cat No: sc-100299|sc-28981|sc-9318|



EphB3 Monoclonal Antibody

Catalogue No.





EphB3 Monoclonal Antibody detects endogenous levels of EphB3 protein.


Purified recombinant fragment of EphB3 (aa39-212) expressed in E Coli





Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000








EphB3 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.


1 mg/ml


EphB3 Antibody was purified using affinity purification.


-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Ephrin type-B receptor 3 antibody, EPH-like tyrosine kinase 2 antibody, EPH-like kinase 2 antibody, Embryonic kinase 2 antibody, EK2 antibody, hEK2 antibody, Tyrosine-protein kinase TYRO6 antibody

Database links

Human UniProt/Swiss-Prot:P54753;Mouse UniPort/Swiss-Prot: P54754;Rat UniProt/Swiss-Port: D3ZH39;Human Entrez Gene: 2049;Mouse Entrez Gene: 13845;Rat Entrez Gene: Rn.131133

Protein names

Ephrin type-B receptor 3 , EPH-like tyrosine kinase 2 , EPH-like kinase 2 , Embryonic kinase 2 , EK2 , hEK2 , Tyrosine-protein kinase TYRO6

Protein function

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Protein tissue specificity


Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. / Contains 1 Eph LBD (Eph ligand-binding) domain. / Contains 2 fibronectin type-III domains. / Contains 1 protein kinase domain. / Contains 1 SAM (sterile alpha motif) domain.

Protein post-translational modifications

Phosphorylated. Autophosphorylates upon ligand-binding. Autophosphorylation on Tyr-614 is required for interaction with SH2 domain-containing proteins.

Protein cellular localization

Cell membrane / Single-pass type I membrane protein / Cell projection > dendrite

Research area

All research areas>Membrane Receptors>EphB3
(View all antibody categories related to Membrane Receptors)


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St John’s Laboratory Ltd.

Product type

Primary antibody


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