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Mouse Monoclonal EphB4 antibody [5B5] (STJ98036)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for EphB4 Monoclonal Antibody.
Check alternative names for the antibodyExpand
EPHB4 antibody, HTK antibody, MYK1 antibody, TYRO11 antibody,||
SCBT cat No: To be updated
EphB4 Monoclonal Antibody
|Catalogue No.|| |
EphB4 Monoclonal Antibody detects endogenous levels of EphB4 protein.
Purified recombinant extracellular fragment of human EphB4 fused with hIgGFc tag expressed in HEK293 cell line
WB, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
EphB4 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
EphB4 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Ephrin type-B receptor 4 antibody, Hepatoma transmembrane kinase antibody, Tyrosine-protein kinase TYRO11 antibody
|Protein names|| |
Ephrin type-B receptor 4 , Hepatoma transmembrane kinase , Tyrosine-protein kinase TYRO11
|Protein function|| |
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
|Protein tissue specificity|| |
Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell lines derived from liver, breast, colon, lung, melanocyte and cervix.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. / Contains 1 Eph LBD (Eph ligand-binding) domain. / Contains 2 fibronectin type-III domains. / Contains 1 protein kinase domain. / Contains 1 SAM (sterile alpha motif) domain.
|Protein post-translational modifications|| |
Phosphorylated; autophosphorylation is stimulated by EFNB2.
|Protein cellular localization|| |
Cell membrane / Single-pass type I membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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