Mouse Monoclonal EphB4 antibody [5B8F7] (STJ98034)

$379.00

Reactivity: Human
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal EphB4 antibody [5B8F7] (STJ98034)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

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Click or hover above images to see image description for EphB4 Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody

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EPHB4 antibody, HTK antibody, MYK1 antibody, TYRO11 antibody,||
SCBT cat No: To be updated

 

Name

EphB4 Monoclonal Antibody

Catalogue No.

STJ98034

Reactivity

Human

Specificity

EphB4 Monoclonal Antibody detects endogenous levels of EphB4 protein.

Immunogen

Purified recombinant fragment of EphB4 expressed in E Coli

Host

Mouse

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG2a

Formulation

EphB4 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

EphB4 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Ephrin type-B receptor 4 antibody, Hepatoma transmembrane kinase antibody, Tyrosine-protein kinase TYRO11 antibody

Database links

Human UniProt/Swiss-Prot:P54760;Mouse UniPort/Swiss-Prot: P54761;Rat UniProt/Swiss-Port: M0RDA4;Human Entrez Gene: 2050;Mouse Entrez Gene: 13846;

Protein names

Ephrin type-B receptor 4 , Hepatoma transmembrane kinase , Tyrosine-protein kinase TYRO11

Protein function

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Protein tissue specificity

Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell lines derived from liver, breast, colon, lung, melanocyte and cervix.

Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. / Contains 1 Eph LBD (Eph ligand-binding) domain. / Contains 2 fibronectin type-III domains. / Contains 1 protein kinase domain. / Contains 1 SAM (sterile alpha motif) domain.

Protein post-translational modifications

Phosphorylated; autophosphorylation is stimulated by EFNB2.

Protein cellular localization

Cell membrane / Single-pass type I membrane protein

Research area

All research areas>Membrane Receptors>Eph
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize EphB4 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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