Mouse Monoclonal EphB6 antibody [2A6B9] (STJ98038)

$379.00

Reactivity: Human
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal EphB6 antibody [2A6B9] (STJ98038)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for EphB6 Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody

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EPHB6 antibody,|EPH receptor B6 antibody|Ephb6 antibody|EPHB6_HUMAN antibody|Ephrin type B receptor 6 precursor antibody|Ephrin type-B receptor 6 antibody|HEP antibody|MGC129910 antibody|MGC129911 antibody|Tyrosine protein kinase defective receptor EPH 6 antibody|Tyrosine-protein kinase-defective receptor EPH-6 antibody|Anti-Eph receptor B6 antibody (ab54656)
SCBT cat No: sc-134332|sc-130053|sc-25461|sc-7282|

 

Name

EphB6 Monoclonal Antibody

Catalogue No.

STJ98038

Reactivity

Human

Specificity

EphB6 Monoclonal Antibody detects endogenous levels of EphB6 protein.

Immunogen

Purified recombinant fragment of EphB6 (aa601-750) expressed in E Coli

Host

Mouse

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

EphB6 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

EphB6 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Ephrin type-B receptor 6 antibody, HEP antibody, Tyrosine-protein kinase-defective receptor EPH-6 antibody

Database links

Human UniProt/Swiss-Prot:O15197;Mouse UniPort/Swiss-Prot: O08644;Rat UniProt/Swiss-Port: P0C0K7;Human Entrez Gene: 2051;Mouse Entrez Gene: 13848;Rat Entrez Gene: Rn.125930

Protein names

Ephrin type-B receptor 6 , HEP , Tyrosine-protein kinase-defective receptor EPH-6

Protein function

Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.

Protein tissue specificity

Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues.

Protein sequence and domain

The protein kinase domain is predicted to be catalytically inactive. Its extracellular domain is capable of promoting cell adhesion and migration in response to low concentrations of ephrin-B2, but its cytoplasmic domain is essential for cell repulsion and inhibition of migration induced by high concentrations of ephrin-B2. / Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. / Contains 1 Eph LBD (Eph ligand-binding) domain. / Contains 2 fibronectin type-III domains. / Contains 1 protein kinase domain. / Contains 1 SAM (sterile alpha motif) domain.

Protein post-translational modifications

Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion.

Protein cellular localization

Membrane; Single-pass type I membrane protein / Secreted

Research area

All research areas>Membrane Receptors>Eph
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize EphB6 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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