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Mouse Monoclonal EphB6 antibody [2A6B9] (STJ98038)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
EPHB6 antibody,|EPH receptor B6 antibody|Ephb6 antibody|EPHB6_HUMAN antibody|Ephrin type B receptor 6 precursor antibody|Ephrin type-B receptor 6 antibody|HEP antibody|MGC129910 antibody|MGC129911 antibody|Tyrosine protein kinase defective receptor EPH 6 antibody|Tyrosine-protein kinase-defective receptor EPH-6 antibody|Anti-Eph receptor B6 antibody (ab54656)
SCBT cat No: sc-134332|sc-130053|sc-25461|sc-7282|
EphB6 Monoclonal Antibody
|Catalogue No.|| |
EphB6 Monoclonal Antibody detects endogenous levels of EphB6 protein.
Purified recombinant fragment of EphB6 (aa601-750) expressed in E Coli
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
EphB6 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
EphB6 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Ephrin type-B receptor 6 antibody, HEP antibody, Tyrosine-protein kinase-defective receptor EPH-6 antibody
|Protein names|| |
Ephrin type-B receptor 6 , HEP , Tyrosine-protein kinase-defective receptor EPH-6
|Protein function|| |
Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
|Protein tissue specificity|| |
Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues.
|Protein sequence and domain|| |
The protein kinase domain is predicted to be catalytically inactive. Its extracellular domain is capable of promoting cell adhesion and migration in response to low concentrations of ephrin-B2, but its cytoplasmic domain is essential for cell repulsion and inhibition of migration induced by high concentrations of ephrin-B2. / Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. / Contains 1 Eph LBD (Eph ligand-binding) domain. / Contains 2 fibronectin type-III domains. / Contains 1 protein kinase domain. / Contains 1 SAM (sterile alpha motif) domain.
|Protein post-translational modifications|| |
Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion.
|Protein cellular localization|| |
Membrane; Single-pass type I membrane protein / Secreted
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St John’s Laboratory Ltd.
|Product type|| |
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