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Mouse Monoclonal ErbB-3 antibody [2B11D11] (STJ98043)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
ERBB3 antibody, HER3 antibody,|c erbB 3 antibody|c erbB3 antibody|Erb b2 receptor tyrosine kinase 3 antibody|ErbB 3 antibody|ERBB3 antibody|ERBB3 protein antibody|erbB3 S antibody|ERBB3_HUMAN antibody|Glial growth factor receptor antibody|HER 3 antibody|HER3 antibody|Human epidermal growth factor receptor 3 antibody|LCCS2 antibody|MDA BF 1 antibody|MGC88033 antibody|p180 ErbB3 antibody|p45 sErbB3 antibody|p85 sErbB3 antibody|proto-oncogene-like protein c ErbB 3 antibody|proto-oncogene-like protein c ErbB3 antibody|Proto-oncogene-like protein c-ErbB-3 antibody|Receptor tyrosine protein kinase erbB 3 antibody|Receptor tyrosine protein kinase erbB3 antibody|Receptor tyrosine-protein kinase erbB-3 antibody|Tyrosine kinase type cell surface receptor HER3 antibody|Tyrosine kinase-type cell surface receptor HER3 antibody|v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody|v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody|v erb b2 erythroblastic leukemia viral oncogene homolog 3 antibody|Anti-ErbB 3 antibody [RTJ2] (ab20161)
SCBT cat No: sc-81454|sc-71067|sc-81455|sc-285|sc-292557|sc-415|sc-53279|sc-71071|
ErbB-3 Monoclonal Antibody
|Catalogue No.|| |
ErbB-3 Monoclonal Antibody detects endogenous levels of ErbB-3 protein.
Purified recombinant fragment of ErbB-3 (aa1175-1275) expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
ErbB-3 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
ErbB-3 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Receptor tyrosine-protein kinase erbB-3 antibody, Proto-oncogene-like protein c-ErbB-3 antibody, Tyrosine kinase-type cell surface receptor HER3 antibody
|Protein names|| |
Receptor tyrosine-protein kinase erbB-3 , Proto-oncogene-like protein c-ErbB-3 , Tyrosine kinase-type cell surface receptor HER3
|Protein function|| |
Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
|Protein tissue specificity|| |
Epithelial tissues and brain.
|Involvement in disease|| |
Lethal congenital contracture syndrome 2 (LCCS2) [MIM:607598]: A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy, and congenital non-progressive joint contractures (arthrogryposis). The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. LCCS2 patients manifest craniofacial/ocular findings, lack of hydrops, multiple pterygia, and fractures, as well as a normal duration of pregnancy and a unique feature of a markedly distended urinary bladder (neurogenic bladder defect). The phenotype suggests a spinal cord neuropathic etiology. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins. / Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (By similarity). Subject to autophosphorylation.
|Protein cellular localization|| |
Cell membrane; Single-pass type I membrane protein / Secreted
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St John’s Laboratory Ltd.
|Product type|| |
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