Mouse Monoclonal ErbB-3 antibody [3F10F6] (STJ98042)

$379.00

Reactivity: Human
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal ErbB-3 antibody [3F10F6] (STJ98042)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

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ERBB3 antibody, HER3 antibody,|c erbB 3 antibody|c erbB3 antibody|Erb b2 receptor tyrosine kinase 3 antibody|ErbB 3 antibody|ERBB3 antibody|ERBB3 protein antibody|erbB3 S antibody|ERBB3_HUMAN antibody|Glial growth factor receptor antibody|HER 3 antibody|HER3 antibody|Human epidermal growth factor receptor 3 antibody|LCCS2 antibody|MDA BF 1 antibody|MGC88033 antibody|p180 ErbB3 antibody|p45 sErbB3 antibody|p85 sErbB3 antibody|proto-oncogene-like protein c ErbB 3 antibody|proto-oncogene-like protein c ErbB3 antibody|Proto-oncogene-like protein c-ErbB-3 antibody|Receptor tyrosine protein kinase erbB 3 antibody|Receptor tyrosine protein kinase erbB3 antibody|Receptor tyrosine-protein kinase erbB-3 antibody|Tyrosine kinase type cell surface receptor HER3 antibody|Tyrosine kinase-type cell surface receptor HER3 antibody|v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody|v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody|v erb b2 erythroblastic leukemia viral oncogene homolog 3 antibody|Anti-ErbB 3 antibody [RTJ2] (ab20161)
SCBT cat No: sc-81454|sc-71067|sc-81455|sc-285|sc-292557|sc-415|sc-53279|sc-71071|

 

Name

ErbB-3 Monoclonal Antibody

Catalogue No.

STJ98042

Reactivity

Human

Specificity

ErbB-3 Monoclonal Antibody detects endogenous levels of ErbB-3 protein.

Immunogen

Purified recombinant fragment of ErbB-3 (aa1175-1275) expressed in E Coli

Host

Mouse

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

ErbB-3 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

ErbB-3 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Receptor tyrosine-protein kinase erbB-3 antibody, Proto-oncogene-like protein c-ErbB-3 antibody, Tyrosine kinase-type cell surface receptor HER3 antibody

Database links

Human UniProt/Swiss-Prot:P21860;Mouse UniPort/Swiss-Prot: Q61526;Rat UniProt/Swiss-Port: Q62799;Human Entrez Gene: 2065;Mouse Entrez Gene: 13867;Rat Entrez Gene: Rn.10228

Protein names

Receptor tyrosine-protein kinase erbB-3 , Proto-oncogene-like protein c-ErbB-3 , Tyrosine kinase-type cell surface receptor HER3

Protein function

Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Protein tissue specificity

Epithelial tissues and brain.

Involvement in disease

Lethal congenital contracture syndrome 2 (LCCS2) [MIM:607598]: A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy, and congenital non-progressive joint contractures (arthrogryposis). The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. LCCS2 patients manifest craniofacial/ocular findings, lack of hydrops, multiple pterygia, and fractures, as well as a normal duration of pregnancy and a unique feature of a markedly distended urinary bladder (neurogenic bladder defect). The phenotype suggests a spinal cord neuropathic etiology. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins. / Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. / Contains 1 protein kinase domain.

Protein post-translational modifications

Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (By similarity). Subject to autophosphorylation.

Protein cellular localization

Cell membrane; Single-pass type I membrane protein / Secreted

Research area

All research areas>Membrane Receptors>ErbB
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize ErbB-3 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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