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Mouse Monoclonal ESET antibody [5H6D4] (STJ98055)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
SETDB1 antibody, KIAA0067 antibody, KMT1E antibody,|AU022152 antibody|EC 220.127.116.11 antibody|ERG-associated protein with SET domain antibody|ESET antibody|H3 K9 HMTase 4 antibody|H3-K9-HMTase 4 antibody|H3-K9-HMTase4 antibody|Histone H3 K9 methyltransferase 4 antibody|Histone H3-K9 methyltransferase 4 antibody|Histone-lysine N-methyltransferase SETDB1 antibody|KG1T antibody|KIAA0067 antibody|KMT1E antibody|Lysine N-methyltransferase 1E antibody|MGC90670 antibody|mKIAA0067 antibody|SET domain bifurcated 1 antibody|Set domain protein, bifurcated, 1 antibody|SETB1_HUMAN antibody|Setdb1 antibody|Anti-KMT1E / SETDB1 antibody – ChIP Grade (ab12317)
SCBT cat No: sc-166621|sc-271553|sc-130437|sc-271488|sc-66884|
ESET Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Monkey
ESET Monoclonal Antibody detects endogenous levels of ESET protein.
Purified recombinant fragment of human ESET expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
ESET Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
ESET Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Histone-lysine N-methyltransferase SETDB1 antibody, ERG-associated protein with SET domain antibody, ESET antibody, Histone H3-K9 methyltransferase 4 antibody, H3-K9-HMTase 4 antibody, Lysine N-methyltransferase 1E antibody, SET domain bifurcated 1 antibody
|Protein names|| |
Histone-lysine N-methyltransferase SETDB1 , ERG-associated protein with SET domain , ESET , Histone H3-K9 methyltransferase 4 , H3-K9-HMTase 4 , Lysine N-methyltransferase 1E , SET domain bifurcated 1
|Protein function|| |
Histone methyltransferase that specifically trimethylates ‘Lys-9’ of histone H3. H3 ‘Lys-9’ trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 ‘Lys-9’ trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone ‘Lys-9’ trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells . Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) . Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing . / S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
|Protein tissue specificity|| |
Widely expressed. High expression in testis.
|Protein sequence and domain|| |
The pre-SET, SET and post-SET domains are all required for methyltransferase activity. The 347-amino-acid insertion in the SET domain has no effect on the catalytic activity. / Isoform 2 lacks all domains required for histone methyltransferase activity. / In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster. / Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. / Contains 1 MBD (methyl-CpG-binding) domain. / Contains 1 post-SET domain. / Contains 1 pre-SET domain. / Contains 1 SET domain. / Contains 2 Tudor domains.
|Protein cellular localization|| |
Nucleus / Chromosome
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St John’s Laboratory Ltd.
|Product type|| |
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