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Mouse Monoclonal Factor VIII antibody [5E9B2] (STJ98059)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
F8 antibody, F8C antibody,|AHF antibody|Antihemophilic factor antibody|Coagulation factor VIII antibody|coagulation factor VIII, procoagulant component antibody|coagulation factor VIIIc antibody|DXS1253E antibody|F8 antibody|F8b antibody|F8c antibody|FA8_HUMAN antibody|factor VIII F8B antibody|Factor VIIIa light chain antibody|FactorVIII antibody|FVIII antibody|Hema antibody|Hemophilia A antibody|Hemophilia, classic antibody|OTTHUMP00000061446 antibody|OTTHUMP00000196174 antibody|Procoagulant component antibody|Anti-Factor VIII antibody [27.4] (ab41188)
SCBT cat No: sc-59508|sc-59510|sc-27651|sc-27649|sc-27650|sc-65947|sc-65948|sc-65949|sc-65950|sc-27647|sc-73597|sc-59514|sc-33583|sc-33584|sc-59512|
Factor VIII Monoclonal Antibody
|Catalogue No.|| |
Factor VIII Monoclonal Antibody detects endogenous levels of Factor VIII protein.
Purified recombinant fragment of Factor VIII expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
Factor VIII Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Factor VIII Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Coagulation factor VIII antibody, Antihemophilic factor antibody, AHF antibody, Procoagulant component antibody
|Protein names|| |
Coagulation factor VIII , Antihemophilic factor , AHF , Procoagulant component
|Protein function|| |
Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa.
|Involvement in disease|| |
Hemophilia A (HEMA) [MIM:306700]: A disorder of blood coagulation characterized by a permanent tendency to hemorrhage. About 50% of patients have severe hemophilia resulting in frequent spontaneous bleeding into joints, muscles and internal organs. Less severe forms are characterized by bleeding after trauma or surgery. . Note: The disease is caused by mutations affecting the gene represented in this entry. Of particular interest for the understanding of the function of F8 is the category of CRM (cross-reacting material) positive patients (approximately 5%) that have considerable amount of F8 in their plasma (at least 30% of normal), but the protein is non-functional; i.e. the F8 activity is much less than the plasma protein level. CRM-reduced is another category of patients in which the F8C antigen and activity are reduced to approximately the same level. Most mutations are CRM negative, and probably affect the folding and stability of the protein.
|Protein sequence and domain|| |
Domain F5/8 type C 2 is responsible for phospholipid-binding and essential for factor VIII activity. / Belongs to the multicopper oxidase family. / Contains 3 F5/8 type A domains. / Contains 2 F5/8 type C domains. / Contains 6 plastocyanin-like domains.
|Protein post-translational modifications|| |
Sulfation on Tyr-1699 is essential for binding vWF.
|Protein cellular localization|| |
Secreted > extracellular space
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St John’s Laboratory Ltd.
|Product type|| |
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