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Mouse Monoclonal Fes antibody [2E3G3; 2G9G1] (STJ98065)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
FES antibody, FPS antibody,|c-fes/fps protein antibody|cFES antibody|Feline sarcoma (Snyder Theilen) viral (v fes)/Fujinami avian sarcoma (PRCII) viral (v fps) oncogene homolog antibody|feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami antibody|Feline sarcoma oncogene antibody|Feline sarcoma/Fujinami avian sarcoma oncogene homolog antibody|fes antibody|FES proto oncogene, tyrosine kinase antibody|FES_HUMAN antibody|FPS antibody|Oncogene FES antibody|Oncogene FES feline sarcoma virus antibody|P93c fes antibody|Proto oncogene tyrosine protein kinase Fes/Fps antibody|Proto-oncogene c-Fes antibody|Proto-oncogene c-Fps antibody|proto-oncogene tyrosine-protein kinase Fes/Fps antibody|Tyrosine-protein kinase Fes/Fps antibody|Anti-FES antibody [EPR3230(2)] (ab108418)
SCBT cat No: sc-81704|sc-81706|sc-7670|sc-377179|sc-166371|sc-25415|sc-7671|
Fes Monoclonal Antibody
|Catalogue No.|| |
Fes Monoclonal Antibody detects endogenous levels of Fes protein.
Purified recombinant fragment of Fer expressed in E Coli
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Fes Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Fes Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Tyrosine-protein kinase Fes/Fps antibody, Feline sarcoma/Fujinami avian sarcoma oncogene homolog antibody, Proto-oncogene c-Fes antibody, Proto-oncogene c-Fps antibody, p93c-fes antibody
|Protein names|| |
Tyrosine-protein kinase Fes/Fps , Feline sarcoma/Fujinami avian sarcoma oncogene homolog , Proto-oncogene c-Fes , Proto-oncogene c-Fps , p93c-fes
|Protein function|| |
Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. / Kinase activity is tightly regulated. Activated in response to signaling from a cell surface receptor. Activation probably requires binding of a substrate via the SH2 domain, plus autophosphorylation at Tyr-713. Present in an inactive form in the absence of activating stimuli.
|Protein tissue specificity|| |
Widely expressed. Detected in adult colon epithelium.
|Involvement in disease|| |
Note: Has been shown to act as proto-oncogene in some types of cancer, possibly due to abnormal activation of the kinase. Has been shown to act as tumor suppressor in other types of cancer. Expressed and present as activated kinase in a subset of acute myeloid leukemia patients; promotes survival of leukemia cells (PubMed:20111072). Expression is absent in K562 leukemia cells; ectopic expression of FSP/FES restores myeloid differentiation (PubMed:2656706). May function as tumor suppressor in colorectal cancer; expression is reduced or absent in samples from some colon cancer patients (PubMed:16455651). Ectopic expression of FSP/FES suppresses anchorage-independent growth in colon cancer cell lines (PubMed:16455651). Up-regulated in prostate cancer, and might be a predictor of recurrence after radical surgery (PubMed:21563194). May promote growth of renal carcinoma cells (PubMed:19082481). .
|Protein sequence and domain|| |
The coiled coil domains are important for regulating the kinase activity. They mediate homooligomerization and probably also interaction with other proteins. / The N-terminal region including the first coiled coil domain mediates interaction with phosphoinositide-containing membranes. / Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. / Contains 1 F-BAR domain. / Contains 1 protein kinase domain. / Contains 1 SH2 domain.
|Protein post-translational modifications|| |
Autophosphorylated on Tyr-713. Phosphorylated by LYN in response to FCER1 activation. Phosphorylated by HCK.
|Protein cellular localization|| |
Cytoplasm > cytosol / Cytoplasm > cytoskeleton / Cell membrane; Peripheral membrane protein; Cytoplasmic side / Cytoplasmic vesicle / Golgi apparatus / Cell junction > focal adhesion
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St John’s Laboratory Ltd.
|Product type|| |
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