Mouse Monoclonal Fes antibody [5A11G5] (STJ98066)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Fes antibody [5A11G5] (STJ98066)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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FES antibody, FPS antibody,|c-fes/fps protein antibody|cFES antibody|Feline sarcoma (Snyder Theilen) viral (v fes)/Fujinami avian sarcoma (PRCII) viral (v fps) oncogene homolog antibody|feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami antibody|Feline sarcoma oncogene antibody|Feline sarcoma/Fujinami avian sarcoma oncogene homolog antibody|fes antibody|FES proto oncogene, tyrosine kinase antibody|FES_HUMAN antibody|FPS antibody|Oncogene FES antibody|Oncogene FES feline sarcoma virus antibody|P93c fes antibody|Proto oncogene tyrosine protein kinase Fes/Fps antibody|Proto-oncogene c-Fes antibody|Proto-oncogene c-Fps antibody|proto-oncogene tyrosine-protein kinase Fes/Fps antibody|Tyrosine-protein kinase Fes/Fps antibody|Anti-FES antibody [EPR3230(2)] (ab108418)
SCBT cat No: sc-81704|sc-81706|sc-7670|sc-377179|sc-166371|sc-25415|sc-7671|

 

Name

Fes Monoclonal Antibody

Catalogue No.

STJ98066

Reactivity

Human

Specificity

Fes Monoclonal Antibody detects endogenous levels of Fes protein.

Immunogen

Purified recombinant fragment of Fer expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

Fes Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

Fes Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Tyrosine-protein kinase Fes/Fps antibody, Feline sarcoma/Fujinami avian sarcoma oncogene homolog antibody, Proto-oncogene c-Fes antibody, Proto-oncogene c-Fps antibody, p93c-fes antibody

Database links

Human UniProt/Swiss-Prot:P07332;Mouse UniPort/Swiss-Prot: P16879;Rat UniProt/Swiss-Port: D4A584;Human Entrez Gene: 2242;Mouse Entrez Gene: 14159;Rat Entrez Gene: Rn.27239

Protein names

Tyrosine-protein kinase Fes/Fps , Feline sarcoma/Fujinami avian sarcoma oncogene homolog , Proto-oncogene c-Fes , Proto-oncogene c-Fps , p93c-fes

Protein function

Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. / Kinase activity is tightly regulated. Activated in response to signaling from a cell surface receptor. Activation probably requires binding of a substrate via the SH2 domain, plus autophosphorylation at Tyr-713. Present in an inactive form in the absence of activating stimuli.

Protein tissue specificity

Widely expressed. Detected in adult colon epithelium.

Involvement in disease

Note: Has been shown to act as proto-oncogene in some types of cancer, possibly due to abnormal activation of the kinase. Has been shown to act as tumor suppressor in other types of cancer. Expressed and present as activated kinase in a subset of acute myeloid leukemia patients; promotes survival of leukemia cells (PubMed:20111072). Expression is absent in K562 leukemia cells; ectopic expression of FSP/FES restores myeloid differentiation (PubMed:2656706). May function as tumor suppressor in colorectal cancer; expression is reduced or absent in samples from some colon cancer patients (PubMed:16455651). Ectopic expression of FSP/FES suppresses anchorage-independent growth in colon cancer cell lines (PubMed:16455651). Up-regulated in prostate cancer, and might be a predictor of recurrence after radical surgery (PubMed:21563194). May promote growth of renal carcinoma cells (PubMed:19082481). .

Protein sequence and domain

The coiled coil domains are important for regulating the kinase activity. They mediate homooligomerization and probably also interaction with other proteins. / The N-terminal region including the first coiled coil domain mediates interaction with phosphoinositide-containing membranes. / Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. / Contains 1 F-BAR domain. / Contains 1 protein kinase domain. / Contains 1 SH2 domain.

Protein post-translational modifications

Autophosphorylated on Tyr-713. Phosphorylated by LYN in response to FCER1 activation. Phosphorylated by HCK.

Protein cellular localization

Cytoplasm > cytosol / Cytoplasm > cytoskeleton / Cell membrane; Peripheral membrane protein; Cytoplasmic side / Cytoplasmic vesicle / Golgi apparatus / Cell junction > focal adhesion

Research area

All research areas>Kinases and Phosphatases>Fes
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize Fes Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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