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Mouse Monoclonal Fibulin-5 antibody [3F10A5; 3F8A12] (STJ98074)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for Fibulin-5 Monoclonal Antibody.
Check alternative names for the antibodyExpand
FBLN5 antibody, DANCE antibody, UNQ184/PRO210 antibody,|ADCL2 antibody|ARCL1A antibody|ARMD3 antibody|Dance antibody|Developmental arteries and neural crest EGF like protein antibody|Developmental arteries and neural crest EGF-like protein antibody|EVEC antibody|Fbln5 antibody|FBLN5_HUMAN antibody|FIBL 5 antibody|FIBL-5 antibody|Fibulin-5 antibody|FLJ90059 antibody|UP50 antibody|Urine p50 protein antibody|Anti-Fibulin 5 antibody [1G6A4] (ab66339)
SCBT cat No: sc-517203|sc-30170|sc-23062|
Fibulin-5 Monoclonal Antibody
|Catalogue No.|| |
Fibulin-5 Monoclonal Antibody detects endogenous levels of Fibulin-5 protein.
Purified recombinant fragment of Fibulin-5 expressed in E Coli
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Fibulin-5 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Fibulin-5 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Fibulin-5 antibody, FIBL-5 antibody, Developmental arteries and neural crest EGF-like protein antibody, Dance antibody, Urine p50 protein antibody, UP50 antibody
|Protein names|| |
Fibulin-5 , FIBL-5 , Developmental arteries and neural crest EGF-like protein , Dance , Urine p50 protein , UP50
|Protein function|| |
Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN . Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling .
|Protein tissue specificity|| |
Expressed in skin fibroblasts (at protein level)(PubMed:17035250). Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes (PubMed:10428823).
|Involvement in disease|| |
Neuropathy, hereditary, with or without age-related macular degeneration (HNARMD) [MIM:608895]: An autosomal dominant neuropathy of the Charcot-Marie-Tooth disease group, characterized by distal muscle weakness and atrophy variably affecting the lower and upper limbs. Distal sensory impairement and decreased nerve conduction velocities are present in most but not all patients. Additional variable features are age-related macular degeneration, joint hypermobility, and hyperelastic skin. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Cutis laxa, autosomal dominant, 2 (ADCL2) [MIM:614434]: A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. Additional variable clinical features are gastrointestinal diverticula, hernia, and genital prolapse. Rare manifestations are pulmonary artery stenosis, aortic aneurysm, bronchiectasis, and emphysema. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Cutis laxa, autosomal recessive, 1A (ARCL1A) [MIM:219100]: A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. The clinical spectrum of autosomal recessive cutis laxa is highly heterogeneous with respect to organ involvement and severity. Type I autosomal recessive cutis laxa is a specific, life-threatening disorder with organ involvement, lung atelectasis and emphysema, diverticula of the gastrointestinal and genitourinary systems, and vascular anomalies. Associated cranial anomalies, late closure of the fontanel, joint laxity, hip dislocation, and inguinal hernia have been observed but are uncommon. . Note: The disease is caused by mutations affecting the gene represented in this entry. Mutations affecting this gene can modify the phenotype of diseases caused by ELN mutations. .; Macular degeneration, age-related, 3 (ARMD3) [MIM:608895]: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the fibulin family. / Contains 6 EGF-like domains.
|Protein post-translational modifications|| |
|Protein cellular localization|| |
Secreted / Secreted > extracellular space > extracellular matrix
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St John’s Laboratory Ltd.
|Product type|| |
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