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Mouse Monoclonal FMR1 antibody [4G9] (STJ98082)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
FMR1 antibody,|FMR 1 antibody|fragile X mental retardation, autosomal homolog 1 antibody|FRAXA antibody|fxr1 antibody|MGC87458 antibody|POF antibody|POF1 antibody|Protein FMR-1 antibody|Protein FMR1 antibody|wu:fb16f11 antibody|wu:fd18c10 antibody|zgc:66226 antibody|Anti-FMRP antibody (ab17722)
SCBT cat No: sc-101048|sc-293156|sc-28739|sc-10547|
FMR1 Monoclonal Antibody
|Catalogue No.|| |
FMR1 Monoclonal Antibody detects endogenous levels of FMR1 protein.
Purified recombinant fragment of human FMR1 expressed in E Coli
WB, IHC, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000
FMR1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
FMR1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Synaptic functional regulator FMR1 antibody, Fragile X mental retardation protein 1 antibody, FMRP antibody, Protein FMR-1 antibody
|Protein names|| |
Synaptic functional regulator FMR1 , Fragile X mental retardation protein 1 , FMRP , Protein FMR-1
|Protein function|| |
Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).
|Protein tissue specificity|| |
Highest levels found in neurons, brain, testis, placenta and lymphocytes. Also expressed in epithelial tissues and at very low levels in glial cells.
|Involvement in disease|| |
Fragile X syndrome (FRAX) [MIM:300624]: Common genetic disease (has a prevalence of one in every 2000 children) which is characterized by moderate to severe mental retardation, macroorchidism (enlargement of the testicles), large ears, prominent jaw, and high-pitched, jocular speech. The defect in most fragile X syndrome patients results from an amplification of a CGG repeat region which is directly in front of the coding region. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Fragile X tremor/ataxia syndrome (FXTAS) [MIM:300623]: In FXTAS, the expanded repeats range in size from 55 to 200 repeats and are referred to as ‘premutations’. Full repeat expansions with greater than 200 repeats results in fragile X mental retardation syndrome [MIM:300624]. Carriers of the premutation typically do not show the full fragile X syndrome phenotype, but comprise a subgroup that may have some physical features of fragile X syndrome or mild cognitive and emotional problems. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Premature ovarian failure 1 (POF1) [MIM:311360]: An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The tandem Tudor domains preferentially recognize trimethylated histone peptides. / Belongs to the FMR1 family. / Contains 2 Agenet-like domains. / Contains 2 KH domains.
|Protein post-translational modifications|| |
Phosphorylated on several serine residues.
|Protein cellular localization|| |
Cytoplasm / Nucleus / Nucleus > nucleolus
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St John’s Laboratory Ltd.
|Product type|| |
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