Mouse Monoclonal FMR1 antibody [4G9] (STJ98082)

$379.00

Reactivity: Human
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal FMR1 antibody [4G9] (STJ98082)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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FMR1 antibody,|FMR 1 antibody|fragile X mental retardation, autosomal homolog 1 antibody|FRAXA antibody|fxr1 antibody|MGC87458 antibody|POF antibody|POF1 antibody|Protein FMR-1 antibody|Protein FMR1 antibody|wu:fb16f11 antibody|wu:fd18c10 antibody|zgc:66226 antibody|Anti-FMRP antibody (ab17722)
SCBT cat No: sc-101048|sc-293156|sc-28739|sc-10547|

 

Name

FMR1 Monoclonal Antibody

Catalogue No.

STJ98082

Reactivity

Human

Specificity

FMR1 Monoclonal Antibody detects endogenous levels of FMR1 protein.

Immunogen

Purified recombinant fragment of human FMR1 expressed in E Coli

Host

Mouse

Applications

WB, IHC, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

FMR1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

FMR1 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Synaptic functional regulator FMR1 antibody, Fragile X mental retardation protein 1 antibody, FMRP antibody, Protein FMR-1 antibody

Database links

Human UniProt/Swiss-Prot:Q06787;Rat UniProt/Swiss-Port: Q80WE1;Human Entrez Gene: 2332;Mouse Entrez Gene: 14265;Rat Entrez Gene: Rn.40595

Protein names

Synaptic functional regulator FMR1 , Fragile X mental retardation protein 1 , FMRP , Protein FMR-1

Protein function

Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).

Protein tissue specificity

Highest levels found in neurons, brain, testis, placenta and lymphocytes. Also expressed in epithelial tissues and at very low levels in glial cells.

Involvement in disease

Fragile X syndrome (FRAX) [MIM:300624]: Common genetic disease (has a prevalence of one in every 2000 children) which is characterized by moderate to severe mental retardation, macroorchidism (enlargement of the testicles), large ears, prominent jaw, and high-pitched, jocular speech. The defect in most fragile X syndrome patients results from an amplification of a CGG repeat region which is directly in front of the coding region. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Fragile X tremor/ataxia syndrome (FXTAS) [MIM:300623]: In FXTAS, the expanded repeats range in size from 55 to 200 repeats and are referred to as ‘premutations’. Full repeat expansions with greater than 200 repeats results in fragile X mental retardation syndrome [MIM:300624]. Carriers of the premutation typically do not show the full fragile X syndrome phenotype, but comprise a subgroup that may have some physical features of fragile X syndrome or mild cognitive and emotional problems. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Premature ovarian failure 1 (POF1) [MIM:311360]: An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

The tandem Tudor domains preferentially recognize trimethylated histone peptides. / Belongs to the FMR1 family. / Contains 2 Agenet-like domains. / Contains 2 KH domains.

Protein post-translational modifications

Phosphorylated on several serine residues.

Protein cellular localization

Cytoplasm / Nucleus / Nucleus > nucleolus

Research area

All research areas>Transcription Regulators>FMR1
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize FMR1 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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