Mouse Monoclonal FoxA2 antibody [7H4B7] (STJ98083)

$379.00

Reactivity: Human
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal FoxA2 antibody [7H4B7] (STJ98083)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for FoxA2 Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody

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FOXA2 antibody, HNF3B antibody, TCF3B antibody,|Forkhead box A2 antibody|Forkhead box protein A2 antibody|FOX A2 antibody|foxa2 antibody|FOXA2_HUMAN antibody|Hepatic nuclear factor 3 beta antibody|Hepatocyte nuclear factor 3 antibody|Hepatocyte nuclear factor 3 beta antibody|Hepatocyte nuclear factor 3-beta antibody|HNF 3B antibody|HNF-3-beta antibody|HNF-3B antibody|HNF3B antibody|MGC19807 antibody|TCF 3B antibody|TCF-3B antibody|TCF3B antibody|Transcription factor 3B antibody|Anti-FOXA2 antibody [EPR4466] (ab108422)
SCBT cat No: sc-377033|sc-374375|sc-271103|sc-20692|sc-374376|sc-271104|sc-6554|sc-9187|sc-101060|

 

Name

FoxA2 Monoclonal Antibody

Catalogue No.

STJ98083

Reactivity

Human

Specificity

FoxA2 Monoclonal Antibody detects endogenous levels of FoxA2 protein.

Immunogen

Purified recombinant fragment of FoxA2 expressed in E Coli

Host

Mouse

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

FoxA2 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

FoxA2 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Hepatocyte nuclear factor 3-beta antibody, HNF-3-beta antibody, HNF-3B antibody, Forkhead box protein A2 antibody, Transcription factor 3B antibody, TCF-3B antibody

Database links

Human UniProt/Swiss-Prot:Q9Y261;Mouse UniPort/Swiss-Prot: P35583;Rat UniProt/Swiss-Port: P32182;Human Entrez Gene: 3170;Mouse Entrez Gene: 15376;Rat Entrez Gene: Rn.10948

Protein names

Hepatocyte nuclear factor 3-beta , HNF-3-beta , HNF-3B , Forkhead box protein A2 , Transcription factor 3B , TCF-3B

Protein function

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ‘pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5′-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3′ (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.

Protein sequence and domain

Contains 1 fork-head DNA-binding domain.

Protein post-translational modifications

Phosphorylation on Thr-156 abolishes binding to target promoters and subsequent transcription activation upon insulin stimulation.

Protein cellular localization

Nucleus / Cytoplasm

Research area

All research areas>Transcription Regulators>HNF
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize FoxA2 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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