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Mouse Monoclonal FoxA2 antibody [7H4B7] (STJ98083)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
FOXA2 antibody, HNF3B antibody, TCF3B antibody,|Forkhead box A2 antibody|Forkhead box protein A2 antibody|FOX A2 antibody|foxa2 antibody|FOXA2_HUMAN antibody|Hepatic nuclear factor 3 beta antibody|Hepatocyte nuclear factor 3 antibody|Hepatocyte nuclear factor 3 beta antibody|Hepatocyte nuclear factor 3-beta antibody|HNF 3B antibody|HNF-3-beta antibody|HNF-3B antibody|HNF3B antibody|MGC19807 antibody|TCF 3B antibody|TCF-3B antibody|TCF3B antibody|Transcription factor 3B antibody|Anti-FOXA2 antibody [EPR4466] (ab108422)
SCBT cat No: sc-377033|sc-374375|sc-271103|sc-20692|sc-374376|sc-271104|sc-6554|sc-9187|sc-101060|
FoxA2 Monoclonal Antibody
|Catalogue No.|| |
FoxA2 Monoclonal Antibody detects endogenous levels of FoxA2 protein.
Purified recombinant fragment of FoxA2 expressed in E Coli
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
FoxA2 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
FoxA2 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Hepatocyte nuclear factor 3-beta antibody, HNF-3-beta antibody, HNF-3B antibody, Forkhead box protein A2 antibody, Transcription factor 3B antibody, TCF-3B antibody
|Protein names|| |
Hepatocyte nuclear factor 3-beta , HNF-3-beta , HNF-3B , Forkhead box protein A2 , Transcription factor 3B , TCF-3B
|Protein function|| |
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ‘pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5′-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3′ (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
|Protein sequence and domain|| |
Contains 1 fork-head DNA-binding domain.
|Protein post-translational modifications|| |
Phosphorylation on Thr-156 abolishes binding to target promoters and subsequent transcription activation upon insulin stimulation.
|Protein cellular localization|| |
Nucleus / Cytoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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