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Mouse Monoclonal G6PD antibody [5E12] (STJ98093)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, FC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
G6PD antibody,|G6PD antibody|G6PD_HUMAN antibody|G6PD1 antibody|G6pdx antibody|Glucose 6 phosphate 1 dehydrogenase antibody|Glucose 6 phosphate dehydrogenase antibody|Glucose 6 phosphate dehydrogenase, G6PD antibody|Glucose-6-phosphate 1-dehydrogenase antibody|MET19 antibody|POS10 antibody|Zwf1p antibody|Anti-Glucose 6 Phosphate Dehydrogenase antibody (ab993)
SCBT cat No: sc-46968|sc-373886|sc-373887|sc-67165|sc-46971|
G6PD Monoclonal Antibody
|Catalogue No.|| |
G6PD Monoclonal Antibody detects endogenous levels of G6PD protein.
Purified recombinant fragment of human G6PD expressed in E Coli
WB, IHC, FC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
G6PD Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
G6PD Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Glucose-6-phosphate 1-dehydrogenase antibody, G6PD antibody,
|Protein names|| |
Glucose-6-phosphate 1-dehydrogenase , G6PD ,
|Protein function|| |
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. / D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH. / 7.07 µM for NADP / 52 µM for glucose 6-phosphate /
|Protein tissue specificity|| |
Isoform Long is found in lymphoblasts, granulocytes and sperm.
|Involvement in disease|| |
Anemia, non-spherocytic hemolytic, due to G6PD deficiency (NSHA) [MIM:300908]: A disease characterized by G6PD deficiency, acute hemolytic anemia, fatigue, back pain, and jaundice. In most patients, the disease is triggered by an exogenous agent, such as some drugs, food, or infection. Increased unconjugated bilirubin, lactate dehydrogenase, and reticulocytosis are markers of the disorder. Although G6PD deficiency can be life-threatening, most patients are asymptomatic throughout their life. . Note: The disease is caused by mutations affecting the gene represented in this entry. Deficiency of G6PD is associated with hemolytic anemia in two different situations. First, in areas in which malaria has been endemic, G6PD-deficiency alleles have reached high frequencies (1% to 50%) and deficient individuals, though essentially asymptomatic in the steady state, have a high risk of acute hemolytic attacks. Secondly, sporadic cases of G6PD deficiency occur at a very low frequencies, and they usually present a more severe phenotype. Several types of NSHA are recognized. Class-I variants are associated with severe NSHA; class-II have an activity <10% of normal; class-III have an activity of 10% to 60% of normal; class-IV have near normal activity.
|Protein sequence and domain|| |
Belongs to the glucose-6-phosphate dehydrogenase family.
|Protein post-translational modifications|| |
Acetylated by ELP3 at Lys-403; acetylation inhibits its homodimerization and enzyme activity. Deacetylated by SIRT2 at Lys-403; deacetylation stimulates its enzyme activity.
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St John’s Laboratory Ltd.
|Product type|| |
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