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Mouse Monoclonal GATA-1 antibody [4F5] (STJ98098)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
GATA1 antibody, ERYF1 antibody, GF1 antibody,|Anemia, X-linked, without thrombocytopenia, included antibody|ERYF 1 antibody|Eryf1 antibody|Erythroid transcription factor antibody|Erythrold transcription factor 1 antibody|GATA 1 antibody|GATA binding factor 1 antibody|GATA binding protein 1 (globin transcription factor 1) antibody|GATA binding protein 1 antibody|GATA-1 antibody|GATA-binding factor 1 antibody|GATA1 antibody|GATA1_HUMAN antibody|GF 1 antibody|GF-1 antibody|GF1 antibody|Globin transcription factor 1 antibody|NF E1 antibody|NF E1 DNA binding protein antibody|NF-E1 DNA-binding protein antibody|NFE 1 antibody|NFE1 antibody|Nuclear factor erythroid 1 antibody|Transcription factor GATA1 antibody|XLANP antibody|XLTDA antibody|XLTT antibody|Anti-GATA1 antibody (ab28839)
SCBT cat No: sc-1233|sc-13053|sc-1234|sc-266|sc-265|sc-267|
GATA-1 Monoclonal Antibody
|Catalogue No.|| |
GATA-1 Monoclonal Antibody detects endogenous levels of GATA-1 protein.
Purified recombinant fragment of human GATA-1 expressed in E Coli
WB, IHC, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000
GATA-1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
GATA-1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Erythroid transcription factor antibody, Eryf1 antibody, GATA-binding factor 1 antibody, GATA-1 antibody, GF-1 antibody, NF-E1 DNA-binding protein antibody
|Protein names|| |
Erythroid transcription factor , Eryf1 , GATA-binding factor 1 , GATA-1 , GF-1 , NF-E1 DNA-binding protein
|Protein function|| |
Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5′-[AT]GATA[AG]-3′ within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS .
|Protein tissue specificity|| |
|Involvement in disease|| |
X-linked dyserythropoietic anemia and thrombocytopenia (XDAT) [MIM:300367]: Disorder characterized by erythrocytes with abnormal size and shape, and paucity of platelets in peripheral blood. The bone marrow contains abundant and abnormally small megakaryocytes. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Thrombocytopenia with beta-thalassemia, X-linked (XLTT) [MIM:314050]: An unusual form of thrombocytopenia associated with beta-thalassemia. Patients have splenomegaly and petechiae, moderate thrombocytopenia, prolonged bleeding time due to platelet dysfunction, reticulocytosis and unbalanced (hemo)globin chain synthesis resembling that of beta-thalassemia minor. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Anemia without thrombocytopenia, X-linked (XLAWT) [MIM:300835]: A form of anemia characterized by abnormal morphology of erythrocytes and granulocytes in peripheral blood, bone marrow dysplasia with hypocellularity of erythroid and granulocytic lineages, and normal or increased number of megakaryocytes. Neutropenia of a variable degree is present in affected individuals. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The two fingers are functionally distinct and cooperate to achieve specific, stable DNA binding. The first finger is necessary only for full specificity and stability of binding, whereas the second one is required for binding (By similarity). / Contains 2 GATA-type zinc fingers.
|Protein post-translational modifications|| |
Highly phosphorylated on serine residues. Phosphorylation on Ser-310 is enhanced on erythroid differentiation. Phosphorylation on Ser-142 promotes sumoylation on Lys-137 (By similarity). / Sumoylation on Lys-137 is enhanced by phosphorylation on Ser-142 and by interaction with PIAS4. Sumoylation with SUMO1 has no effect on transcriptional activity (By similarity). / Acetylated at 2 conserved lysine-rich motifs by CREBBP in vitro. Acetylation does not affect DNA-binding in vitro but is essential to induce erythroid differentiation and for binding chromatin in vivo (By similarity). Acetylated on Lys-233, Lys-245 Lys-246 by EP300.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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