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Mouse Monoclonal GATA-4 antibody [6H10] (STJ98101)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
GATA4 antibody,|ASD2 antibody|GATA 4 antibody|GATA binding protein 4 antibody|GATA-binding factor 4 antibody|gata4 antibody|GATA4_HUMAN antibody|MGC126629 antibody|Transcription factor GATA 4 antibody|Transcription factor GATA-4 antibody|Transcription factor GATA4 antibody|VSD1 antibody|Anti-GATA4 antibody (ab84593)
SCBT cat No: sc-1237|sc-25310|sc-9053|sc-515437|sc-47600|
GATA-4 Monoclonal Antibody
|Catalogue No.|| |
GATA-4 Monoclonal Antibody detects endogenous levels of GATA-4 protein.
Purified recombinant fragment of human GATA-4 expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
GATA-4 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
GATA-4 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Transcription factor GATA-4 antibody, GATA-binding factor 4 antibody
|Protein names|| |
Transcription factor GATA-4 , GATA-binding factor 4
|Protein function|| |
Transcriptional activator that binds to the consensus sequence 5′-AGATAG-3′ and plays a key role in cardiac development . Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement . Required during testicular development . May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase .
|Involvement in disease|| |
Atrial septal defect 2 (ASD2) [MIM:607941]: A congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. Patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. The disease is not associated with defects in the cardiac conduction system or non-cardiac abnormalities. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Ventricular septal defect 1 (VSD1) [MIM:614429]: A common form of congenital cardiovascular anomaly that may occur alone or in combination with other cardiac malformations. It can affect any portion of the ventricular septum, resulting in abnormal communications between the two lower chambers of the heart. Classification is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect. Large defects that go unrepaired may give rise to cardiac enlargement, congestive heart failure, pulmonary hypertension, Eisenmenger’s syndrome, delayed fetal brain development, arrhythmias, and even sudden cardiac death. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Tetralogy of Fallot (TOF) [MIM:187500]: A congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Atrioventricular septal defect 4 (AVSD4) [MIM:614430]: A congenital heart malformation characterized by a common atrioventricular junction coexisting with deficient atrioventricular septation. The complete form involves underdevelopment of the lower part of the atrial septum and the upper part of the ventricular septum; the valve itself is also shared. A less severe form, known as ostium primum atrial septal defect, is characterized by separate atrioventricular valvar orifices despite a common junction. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Testicular anomalies with or without congenital heart disease (TACHD) [MIM:615542]: A 46,XY disorder of sex development with variable clinical presentation and defects in testicular differentiation and function. Clinical features include ambiguous genitalia, fused labioscrotal folds, hypospadias, microphallus, and bilateral inguinal hernia containing gonads. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Note: GATA4 mutations can predispose to dilated cardiomyopathy (CMD), a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. .
|Protein sequence and domain|| |
Contains 2 GATA-type zinc fingers.
|Protein post-translational modifications|| |
Methylation at Lys-300 attenuates transcriptional activity.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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