Mouse Monoclonal GATA-5 antibody [1B11] (STJ98102)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal GATA-5 antibody [1B11] (STJ98102)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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GATA5 antibody,|GATA binding protein 5 antibody|GATA-binding factor 5 antibody|GATA5 antibody|GATA5_HUMAN antibody|Transcription factor GATA-5 antibody|Anti-GATA5 antibody (ab48820)
SCBT cat No: sc-373684|sc-373683|sc-515422|sc-7280|

 

Name

GATA-5 Monoclonal Antibody

Catalogue No.

STJ98102

Reactivity

Human

Specificity

GATA-5 Monoclonal Antibody detects endogenous levels of GATA-5 protein.

Immunogen

Purified recombinant fragment of human GATA-5 expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

GATA-5 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

GATA-5 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Transcription factor GATA-5 antibody, GATA-binding factor 5 antibody

Database links

Human UniProt/Swiss-Prot:Q9BWX5;Mouse UniPort/Swiss-Prot: P97489;Rat UniProt/Swiss-Port: Q5U2V0;Human Entrez Gene: 140628;Mouse Entrez Gene: 14464;Rat Entrez Gene: Rn.27175

Protein names

Transcription factor GATA-5 , GATA-binding factor 5

Protein function

Transcription factor required during cardiovascular development . Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer .

Involvement in disease

Note: Rare variants in GATA5 may be a cause of susceptibility to atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. .; Note: Rare variants in GATA5 may be a cause of susceptibility to Tetraology of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis. .; Note: Rare variants in GATA5 may be a cause of susceptibility to ventriculoseptal defect (VSD). VSD is a congenital heart disease which may lead to cardiac enlargement, ventricular dysfunction or heart failure, poor quality of life, pulmonary hypertension, Eisenmenger’s syndrome, delayed fetal brain development, arrhythmias, and even sudden cardiac death in the absence of surgical treatment or transcatheter repair. .; Note: Rare variants in GATA5 may be a cause of susceptibility to aortic valve disease (AOVD). AOVD is a common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification, stenosis and insufficiency. In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome. .; Note: Rare variants in GATA5 may be a cause of susceptibility to dilated cardiomyopathy (CMD). CMD is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. .

Protein sequence and domain

Contains 2 GATA-type zinc fingers.

Protein cellular localization

Nucleus

Research area

All research areas>Transcription Regulators>GATA-5
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize GATA-5 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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