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Mouse Monoclonal GATA-5 antibody [1B11] (STJ98102)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
GATA5 antibody,|GATA binding protein 5 antibody|GATA-binding factor 5 antibody|GATA5 antibody|GATA5_HUMAN antibody|Transcription factor GATA-5 antibody|Anti-GATA5 antibody (ab48820)
SCBT cat No: sc-373684|sc-373683|sc-515422|sc-7280|
GATA-5 Monoclonal Antibody
|Catalogue No.|| |
GATA-5 Monoclonal Antibody detects endogenous levels of GATA-5 protein.
Purified recombinant fragment of human GATA-5 expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
GATA-5 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
GATA-5 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Transcription factor GATA-5 antibody, GATA-binding factor 5 antibody
|Protein names|| |
Transcription factor GATA-5 , GATA-binding factor 5
|Protein function|| |
Transcription factor required during cardiovascular development . Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer .
|Involvement in disease|| |
Note: Rare variants in GATA5 may be a cause of susceptibility to atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. .; Note: Rare variants in GATA5 may be a cause of susceptibility to Tetraology of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis. .; Note: Rare variants in GATA5 may be a cause of susceptibility to ventriculoseptal defect (VSD). VSD is a congenital heart disease which may lead to cardiac enlargement, ventricular dysfunction or heart failure, poor quality of life, pulmonary hypertension, Eisenmenger’s syndrome, delayed fetal brain development, arrhythmias, and even sudden cardiac death in the absence of surgical treatment or transcatheter repair. .; Note: Rare variants in GATA5 may be a cause of susceptibility to aortic valve disease (AOVD). AOVD is a common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification, stenosis and insufficiency. In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome. .; Note: Rare variants in GATA5 may be a cause of susceptibility to dilated cardiomyopathy (CMD). CMD is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. .
|Protein sequence and domain|| |
Contains 2 GATA-type zinc fingers.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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