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Mouse Monoclonal GCG antibody [2F9] (STJ98103)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for GCG Monoclonal Antibody.
Check alternative names for the antibodyExpand
GCG antibody,|GCG antibody|GLP-1 antibody|GLP-1(7-36) antibody|GLP-1(7-37) antibody|GLP-2 antibody|GLP1 antibody|GLP1, included antibody|GLP2 antibody|GLP2, included antibody|GLUC_HUMAN antibody|Glucagon antibody|Glucagon like peptide 1 antibody|glucagon-like peptide 1 antibody|Glucagon-like peptide 1, included antibody|Glucagon-like peptide 2 antibody|Glucagon-like peptide 2, included antibody|GRPP antibody|OXM antibody|OXY antibody|preproglucagon antibody|Anti-Glucagon antibody [K79bB10] (ab10988)
SCBT cat No: sc-65388|sc-65389|sc-80603|sc-57164|sc-80604|sc-57510|sc-71150|sc-71151|sc-80602|sc-80574|sc-167994|sc-7782|sc-167995|sc-26637|sc-167996|sc-57165|sc-57166|sc-57167|sc-57168|sc-73508|sc-167998|sc-167999|sc-390773|sc-390774|sc-66911|sc-392088|sc-34637|
GCG Monoclonal Antibody
|Catalogue No.|| |
GCG Monoclonal Antibody detects endogenous levels of GCG protein.
Purified recombinant fragment of human GCG expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
GCG Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
GCG Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
|Protein names|| |
|Protein function|| |
Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. / GLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis. / GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. / Oxyntomodulin significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness. / Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.
|Protein tissue specificity|| |
Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP-1 and GLP-2 are also secreted in selected neurons in the brain.
|Protein sequence and domain|| |
Belongs to the glucagon family.
|Protein post-translational modifications|| |
Proglucagon is post-translationally processed in a tissue-specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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