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Mouse Monoclonal GCK antibody [4G6] (STJ98104)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
GCK antibody,|ATP:D-hexose 6-phosphotransferase antibody|FGQTL3 antibody|GCK antibody|GK antibody|GLK antibody|Glucokinase antibody|Hexokinase D pancreatic isozyme antibody|Hexokinase type IV antibody|Hexokinase-4 antibody|Hexokinase-D antibody|HHF3 antibody|HK IV antibody|HK4 antibody|HKIV antibody|HXK4_HUMAN antibody|HXKP antibody|LGLK antibody|MODY2 antibody|Anti-Glucokinase antibody – N-terminal (ab37796)
SCBT cat No: sc-55496|sc-17819|sc-7908|sc-1980|sc-130765|
GCK Monoclonal Antibody
|Catalogue No.|| |
GCK Monoclonal Antibody detects endogenous levels of GCK protein.
Purified recombinant fragment of human GCK expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
GCK Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
GCK Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Glucokinase antibody, Hexokinase type IV antibody, HK IV antibody, Hexokinase-4 antibody, HK4 antibody, Hexokinase-D antibody
|Protein names|| |
Glucokinase , Hexokinase type IV , HK IV , Hexokinase-4 , HK4 , Hexokinase-D
|Protein function|| |
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage. / ATP + D-glucose = ADP + D-glucose 6-phosphate. / The use of alternative promoters apparently enables the type IV hexokinase gene to be regulated by insulin in the liver and glucose in the beta cell. This may constitute an important feedback loop for maintaining glucose homeostasis. Subject to allosteric regulation. Low glucose and high fructose-6-phosphate triggers association with the inhibitor GKRP followed by sequestration in the nucleus.
|Protein tissue specificity|| |
Isoform 1 is expressed in pancreas. Isoform 2 and isoform 3 is expressed in liver.
|Involvement in disease|| |
Maturity-onset diabetes of the young 2 (MODY2) [MIM:125851]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Familial hyperinsulinemic hypoglycemia 3 (HHF3) [MIM:602485]: Most common cause of persistent hypoglycemia in infancy. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the hexokinase family. / Contains 1 hexokinase domain.
|Protein cellular localization|| |
Cytoplasm / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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