Mouse Monoclonal GCK antibody [4G6] (STJ98104)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal GCK antibody [4G6] (STJ98104)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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GCK antibody,|ATP:D-hexose 6-phosphotransferase antibody|FGQTL3 antibody|GCK antibody|GK antibody|GLK antibody|Glucokinase antibody|Hexokinase D pancreatic isozyme antibody|Hexokinase type IV antibody|Hexokinase-4 antibody|Hexokinase-D antibody|HHF3 antibody|HK IV antibody|HK4 antibody|HKIV antibody|HXK4_HUMAN antibody|HXKP antibody|LGLK antibody|MODY2 antibody|Anti-Glucokinase antibody – N-terminal (ab37796)
SCBT cat No: sc-55496|sc-17819|sc-7908|sc-1980|sc-130765|

 

Name

GCK Monoclonal Antibody

Catalogue No.

STJ98104

Reactivity

Human

Specificity

GCK Monoclonal Antibody detects endogenous levels of GCK protein.

Immunogen

Purified recombinant fragment of human GCK expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

GCK Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

GCK Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Glucokinase antibody, Hexokinase type IV antibody, HK IV antibody, Hexokinase-4 antibody, HK4 antibody, Hexokinase-D antibody

Database links

Human UniProt/Swiss-Prot:P35557;Mouse UniPort/Swiss-Prot: P52792;Rat UniProt/Swiss-Port: Q64596;Human Entrez Gene: 2645;Mouse Entrez Gene: 103988;Rat Entrez Gene: Rn.10447

Protein names

Glucokinase , Hexokinase type IV , HK IV , Hexokinase-4 , HK4 , Hexokinase-D

Protein function

Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage. / ATP + D-glucose = ADP + D-glucose 6-phosphate. / The use of alternative promoters apparently enables the type IV hexokinase gene to be regulated by insulin in the liver and glucose in the beta cell. This may constitute an important feedback loop for maintaining glucose homeostasis. Subject to allosteric regulation. Low glucose and high fructose-6-phosphate triggers association with the inhibitor GKRP followed by sequestration in the nucleus.

Protein tissue specificity

Isoform 1 is expressed in pancreas. Isoform 2 and isoform 3 is expressed in liver.

Involvement in disease

Maturity-onset diabetes of the young 2 (MODY2) [MIM:125851]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Familial hyperinsulinemic hypoglycemia 3 (HHF3) [MIM:602485]: Most common cause of persistent hypoglycemia in infancy. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the hexokinase family. / Contains 1 hexokinase domain.

Protein cellular localization

Cytoplasm / Nucleus

Research area

All research areas>Kinases and Phosphatases>GCK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize GCK Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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