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Mouse Monoclonal Gfi-1 antibody [5D7] (STJ98107)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for Gfi-1 Monoclonal Antibody.
Check alternative names for the antibodyExpand
GFI1 antibody, ZNF163 antibody,|GFI 1 antibody|GFI1 antibody|GFI1_HUMAN antibody|Growth factor independence 1 antibody|Growth factor independent 1 antibody|Growth factor independent protein 1 antibody|SCN2 antibody|Zinc finger protein 163 antibody|Zinc finger protein Gfi 1 antibody|Zinc finger protein Gfi-1 antibody|Zinc finger protein Gfi1 antibody|ZNF 163 antibody|ZNF163 antibody|Anti-GFI1 antibody (ab21061)
SCBT cat No: sc-101053|sc-376949|sc-373960|sc-22796|sc-6357|sc-8558|
Gfi-1 Monoclonal Antibody
|Catalogue No.|| |
Gfi-1 Monoclonal Antibody detects endogenous levels of Gfi-1 protein.
Purified recombinant fragment of human Gfi-1 expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
Gfi-1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Gfi-1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Zinc finger protein Gfi-1 antibody, Growth factor independent protein 1 antibody, Zinc finger protein 163 antibody
|Protein names|| |
Zinc finger protein Gfi-1 , Growth factor independent protein 1 , Zinc finger protein 163
|Protein function|| |
Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5′-TAAATCAC[AT]GCA-3′ in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells.
|Protein tissue specificity|| |
Down-regulated by TGFB1.
|Involvement in disease|| |
Neutropenia, severe congenital 2, autosomal dominant (SCN2) [MIM:613107]: A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA) [MIM:607847]: Relatively mild form of neutropenia diagnosed in adults, but predisposing to leukemia in a subset of patients. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Zinc fingers 3, 4 and 5 are required for DNA-binding and for interaction with SPI1. / The SNAG domain of GFIs is required for nuclear location and for interaction with some corepressors. / Contains 6 C2H2-type zinc fingers.
|Protein post-translational modifications|| |
Ubiquitinated. Ubiquitination and degradation by the proteasome is inhibited by the ubiquitin ligase, ARIH2.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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