Mouse Monoclonal GluR-3 antibody [1D2] (STJ98111)

$379.00

Reactivity: Human
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal GluR-3 antibody [1D2] (STJ98111)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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GRIA3 antibody, GLUR3 antibody, GLURC antibody,|AMPA 3 antibody|AMPA selective glutamate receptor 3 antibody|AMPA-selective glutamate receptor 3 antibody|dJ1171F9.1 antibody|GluA3 antibody|GLUK3 antibody|GluR 3 antibody|GLUR C antibody|GLUR K3 antibody|GluR-3 antibody|GluR-C antibody|GluR-K3 antibody|GLUR3 antibody|GLURC antibody|Glutamate ionotropic receptor AMPA type subunit 3 antibody|Glutamate receptor 3 antibody|Glutamate receptor C antibody|Glutamate receptor ionotrophic AMPA 3 antibody|Glutamate receptor ionotropic antibody|Glutamate receptor subunit 3 antibody|Glutamate receptor, ionotropic, AMPA 3 antibody|GRIA 3 antibody|Gria3 antibody|GRIA3_HUMAN antibody|Ionotrophic Glutamate Receptor antibody|MRX94 antibody|Anti-Glutamate receptor 3 antibody [EP813Y] (ab40845)
SCBT cat No: sc-7612|sc-7613|

 

Name

GluR-3 Monoclonal Antibody

Catalogue No.

STJ98111

Reactivity

Human

Specificity

GluR-3 Monoclonal Antibody detects endogenous levels of GluR-3 protein.

Immunogen

Purified recombinant fragment of human GluR-3 expressed in E Coli

Host

Mouse

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

GluR-3 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

GluR-3 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Glutamate receptor 3 antibody, GluR-3 antibody, AMPA-selective glutamate receptor 3 antibody, GluR-C antibody, GluR-K3 antibody, Glutamate receptor ionotropic, AMPA 3 antibody, GluA3 antibody

Database links

Human UniProt/Swiss-Prot:P42263;Mouse UniPort/Swiss-Prot: Q9Z2W9;Rat UniProt/Swiss-Port: P19492;Human Entrez Gene: 2892;Mouse Entrez Gene: 53623;Rat Entrez Gene: Rn.74049

Protein names

Glutamate receptor 3 , GluR-3 , AMPA-selective glutamate receptor 3 , GluR-C , GluR-K3 , Glutamate receptor ionotropic, AMPA 3 , GluA3

Protein function

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Involvement in disease

Mental retardation, X-linked 94 (MRX94) [MIM:300699]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. MRX94 patients have moderate mental retardation. Other variable features are macrocephaly, seizures, myoclonic jerks, autistic behavior, asthenic body habitus, distal muscle weakness and hyporeflexia. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

The M4 transmembrane segment mediates tetramerization and is required for cell surface expression. / Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA3 subfamily. [View classification]

Protein post-translational modifications

Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-621 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-847 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).

Protein cellular localization

Cell membrane; Multi-pass membrane protein / Cell junction > synapse > postsynaptic cell membrane; Multi-pass membrane protein

Research area

All research areas>Channel Proteins>GluR-3
(View all antibody categories related to Channel Proteins)

Note

AntibodyPlus can customize GluR-3 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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