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Mouse Monoclonal GluR-3 antibody [1D2] (STJ98111)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
GRIA3 antibody, GLUR3 antibody, GLURC antibody,|AMPA 3 antibody|AMPA selective glutamate receptor 3 antibody|AMPA-selective glutamate receptor 3 antibody|dJ1171F9.1 antibody|GluA3 antibody|GLUK3 antibody|GluR 3 antibody|GLUR C antibody|GLUR K3 antibody|GluR-3 antibody|GluR-C antibody|GluR-K3 antibody|GLUR3 antibody|GLURC antibody|Glutamate ionotropic receptor AMPA type subunit 3 antibody|Glutamate receptor 3 antibody|Glutamate receptor C antibody|Glutamate receptor ionotrophic AMPA 3 antibody|Glutamate receptor ionotropic antibody|Glutamate receptor subunit 3 antibody|Glutamate receptor, ionotropic, AMPA 3 antibody|GRIA 3 antibody|Gria3 antibody|GRIA3_HUMAN antibody|Ionotrophic Glutamate Receptor antibody|MRX94 antibody|Anti-Glutamate receptor 3 antibody [EP813Y] (ab40845)
SCBT cat No: sc-7612|sc-7613|
GluR-3 Monoclonal Antibody
|Catalogue No.|| |
GluR-3 Monoclonal Antibody detects endogenous levels of GluR-3 protein.
Purified recombinant fragment of human GluR-3 expressed in E Coli
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
GluR-3 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
GluR-3 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Glutamate receptor 3 antibody, GluR-3 antibody, AMPA-selective glutamate receptor 3 antibody, GluR-C antibody, GluR-K3 antibody, Glutamate receptor ionotropic, AMPA 3 antibody, GluA3 antibody
|Protein names|| |
Glutamate receptor 3 , GluR-3 , AMPA-selective glutamate receptor 3 , GluR-C , GluR-K3 , Glutamate receptor ionotropic, AMPA 3 , GluA3
|Protein function|| |
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
|Involvement in disease|| |
Mental retardation, X-linked 94 (MRX94) [MIM:300699]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. MRX94 patients have moderate mental retardation. Other variable features are macrocephaly, seizures, myoclonic jerks, autistic behavior, asthenic body habitus, distal muscle weakness and hyporeflexia. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The M4 transmembrane segment mediates tetramerization and is required for cell surface expression. / Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA3 subfamily. [View classification]
|Protein post-translational modifications|| |
Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-621 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-847 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
|Protein cellular localization|| |
Cell membrane; Multi-pass membrane protein / Cell junction > synapse > postsynaptic cell membrane; Multi-pass membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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