Mouse Monoclonal GRK 2 antibody [3F8] (STJ98116)

$379.00

Reactivity: Human, Mouse, Rat, Monkey
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal GRK 2 antibody [3F8] (STJ98116)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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ADRBK1 antibody, BARK antibody, BARK1 antibody, GRK2 antibody,|ADRBK1 antibody|Adrenergic beta receptor kinase 1 antibody|ARBK1_HUMAN antibody|BARK antibody|BARK1 antibody|Beta adrenergic receptor kinase 1 antibody|Beta ARK 1 antibody|Beta ARK1 antibody|Beta-adrenergic receptor kinase 1 antibody|Beta-ARK-1 antibody|FLJ16718 antibody|G protein coupled receptor kinase 2 antibody|G-protein coupled receptor kinase 2 antibody|GRK2 antibody|Anti-GRK2 antibody – C-terminal (ab137666)
SCBT cat No: sc-562|sc-18409|sc-13143|sc-166283|sc-166284|sc-271359|sc-8329|

 

Name

GRK 2 Monoclonal Antibody

Catalogue No.

STJ98116

Reactivity

Human, Mouse, Rat, Monkey

Specificity

GRK 2 Monoclonal Antibody detects endogenous levels of GRK 2 protein.

Immunogen

Purified recombinant fragment of human GRK 2 expressed in E Coli

Host

Mouse

Applications

WB, IHC, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

GRK 2 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

GRK 2 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Beta-adrenergic receptor kinase 1 antibody, Beta-ARK-1 antibody, G-protein coupled receptor kinase 2 antibody

Database links

Human UniProt/Swiss-Prot:P25098;Mouse UniPort/Swiss-Prot: Q99MK8;Rat UniProt/Swiss-Port: P26817;Human Entrez Gene: 156;Mouse Entrez Gene: 110355;Rat Entrez Gene: Rn.13010

Protein names

Beta-adrenergic receptor kinase 1 , Beta-ARK-1 , G-protein coupled receptor kinase 2

Protein function

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. / ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate. / In contrast to other AGC family kinases, the catalytic activity is solely regulated by the binding of substrates and ligands, not by phosphorylation of the kinase domain.

Protein tissue specificity

Expressed in peripheral blood leukocytes.

Protein sequence and domain

The PH domain binds anionic phospholipids and helps recruiting ADRBK1 from the cytoplasm to plasma membrane close to activated receptors. It mediates binding to G protein beta and gamma subunits, competing with G-apha subunits and other G-betagamma effectors. / Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. / Contains 1 AGC-kinase C-terminal domain. / Contains 1 PH domain. / Contains 1 protein kinase domain. / Contains 1 RGS domain.

Protein cellular localization

Cytoplasm / Cell membrane

Research area

All research areas>Kinases and Phosphatases>GRK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize GRK 2 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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