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Mouse Monoclonal GSK3alpha antibody [9D5G1] (STJ98118)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
GSK3A antibody,|Factor A antibody|Glycogen synthase kinase 3 alpha antibody|Glycogen synthase kinase 3 beta antibody|GSK3 alpha antibody|GSK3 beta antibody|GSK3B antibody|Phospho anti-GSK3 (alpha + beta) (Y216 + Y279) antibody [EPR933Y] (ab68476)
SCBT cat No: sc-7291|sc-56913|sc-81462|sc-53931|sc-71186|sc-71188|sc-377213|sc-9166|sc-8257|sc-164567|sc-164569|sc-365863|sc-28966|sc-166882|sc-100546|sc-398714|
GSK3alpha Monoclonal Antibody
|Catalogue No.|| |
GSK3alpha Monoclonal Antibody detects endogenous levels of GSK3alpha protein.
Purified recombinant fragment of GSK3alpha expressed in E Coli
WB, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
GSK3alpha Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
GSK3alpha Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Glycogen synthase kinase-3 alpha antibody, GSK-3 alpha antibody, Serine/threonine-protein kinase GSK3A antibody,
|Protein names|| |
Glycogen synthase kinase-3 alpha , GSK-3 alpha , Serine/threonine-protein kinase GSK3A ,
|Protein function|| |
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. / ATP + [tau protein] = ADP + [tau protein] phosphate. / ATP + a protein = ADP + a phosphoprotein. / Activated by phosphorylation at Tyr-279. In response to insulin, inhibited by phosphorylation at Ser-21 by PKB/AKT1; phosphorylation at this site causes a conformational change, preventing access of substrates to the active site. Inhibited by lithium.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Phosphorylated by AKT1 at Ser-21: upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and desactivates GSK3A, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-279.
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St John’s Laboratory Ltd.
|Product type|| |
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